HIV & AIDS 2025

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Across
  1. 2. Daily use of a combination of antivirals against HIV.
  2. 3. Individuals who maintain normal CD4 counts and undetectable viral loads (<50 copies HIV RNA/ml of plasma) for >10 years in the absence of antiretroviral therapy.
  3. 4. Can transport HIV into the lymph nodes.
  4. 6. Viral proteins translated from unspliced mRNA.
  5. 10. Major reservoir compartment where HIV is maintained in long live cells.
  6. 12. Types of antibodies needed to be elicited by HIV vaccines to be effective
  7. 13. AIDS develop in these individuals within three years.
  8. 15. Blood compartment where more than 10 billion HIV particles are produced and destroyed daily.
  9. 17. Two main HIV viral genotypes originated by separate introductions into humans.
  10. 20. Simian lentivirus that crossed into humans to establish origins of HIV.
Down
  1. 1. AIDS develop slowly in these individuals between 3 to 10 years.
  2. 5. First opportunistic infection identified in HIV infected individuals during the early 80’s.
  3. 7. Loss of immune competence enables benign pathogens such as other viruses, fungi, or protozoa to cause infections on HIV infected individuals.
  4. 8. Viral proteins translated from spliced mRNA.
  5. 9. Cancer that was common pre-ART in HIV infected individuals reactivation of human herpesvirus 8 is required to trigger this cancer.
  6. 11. Major co-receptor for T cell-tropic HIV
  7. 14. First long-acting antiretroviral drug for HIV prophylaxis.
  8. 16. Group of retrovirus HIV belongs to.
  9. 18. Major co-receptor for Mφ-tropic HIV
  10. 19. HIV accessory protein that associates with CD4 and MHCI molecules and direct their degradation.