Huntington's Disease (HD)

1. Gene affected that causes HD
6. most affected neurotransmitters (put in alphabetical order)
7. Huntingon's Disease is a _____ disorder
9. More affected genes with repeat will likely indicate ____
10. Term for genetically confirmed HD patients that show no symptoms or changes in function
12. _____ cases account for 6-8% of new diagnoses
13. acronym for DNA repeats that cause HD
15. In stage four of HD, the capacity to perform ADLs is _____ impaired
17. Most used rating scale for diagnosing (acronym)
19. affected parent has ____ percent chance of passing onto offspring (spell number out)
21. at least ______ repeats are needed for HD diagnosis (spell number out)
24. Part of brain most affected
25. Striatum will likely be the ____ CNS area affected by HD
26. chromosome affected that causes HD
27. Someone in the prodromal phase might have slight ____ deficits
28. term where some individuals will not display the trait although they carry the allele
29. term where all individuals with genetic mutation will have clinical symptoms of disease

2. in stage five of HD, care is most likely provided at a _____.
3. stage when the capacity to manage domestic responsibilities becomes impaired
4. stage of HD when slight assistance is needed to handle financial affairs
5. Higher scores in motor, cognitive, and behavioral domains indicate more ____ disease
8. Someone in the manifest phase will have signs that impact ______.
11. correlates with number of repeats
14. Huntington gene mutations and build up of ____ protein contributes to neuronal dysfunction and death (acronym)
16. Abbreviation of gene affected that causes HD
18. HD causes gradual degeneration of the ___
20. the prodromal phase lasts ____
22. Stage where cognitive changes are likely
23. Someone in the _____ phase might have subtle motor signs