IMM crossword puzzle

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Across
  1. 7. acute phase protein that binds to phosphocholine, a constituent of certain bacteria that can trigger Complement activation and acts as an opsonin
  2. 10. name of MHC gene complex and proteins in humans
  3. 11. soluble acute phase response protein that can bind mannose on pathogens can activate the lectin pathway of Complement and acts as an opsonin
  4. 17. a type of APC that presents antigen in the context of MHC to T cells
  5. 19. human immunodeficiency virus
  6. 20. a cytokine produced by macrophages and T cells that is highly pro-inflammatory
  7. 23. protein family to which antibodies and B-cell receptors belong
  8. 24. an autoimmune disease where autoantibodies form immune complexes
  9. 25. family name for cytokines that help cells to resist viral infections
  10. 26. general designation of many of the different cytokines, chemical messengers secreted by immune cells that help in their communication with other cells
Down
  1. 1. a family of Pattern Recognition Receptors present on many leukocytes and epithelial cells that recognize PAMPs on pathogens and help initiate immune responses
  2. 2. the two genes essential for Ig and TCR gene rearrangement
  3. 3. an immunoglobulin that is expressed on B cell surface
  4. 4. designation for a family of cell surface molecules involved in the presentation of peptide antigens to T cells
  5. 5. the Ag receptor on T cells
  6. 6. a crystallized fragment of an antibody
  7. 8. receptors on immune cells and epithelial cells that recognize and bind to PAMPs on microbes
  8. 9. cells surface ligands for the leukocyte integrins
  9. 12. end product of the Complement cascade that can kill pathogens directly by forming a pore in pathogen membrane leading to lysis
  10. 13. large mononuclear phagocyte that takes residence in many different tissues and organs and contributes to innate immune responses and can act as an effector cell in adaptive immune responses
  11. 14. short DNA sequences flanking Ig and TCR V D and J gene segments that serve as the binding sites for the RAG complex allowing Ig and TCR gene rearrangement
  12. 15. white blood cells with multi-lobed nuclei and cytoplasmic granules
  13. 16. Member of TNF receptor family expressed on certain cells that makes them susceptible to being killed by cells expressing the Fas ligand
  14. 18. a cell wall component of gram-negative bacteria which can be bound by TLR-4 on macrophages and dendritic cells
  15. 21. large granular lymphocyte that serves as an innate effector cell by inducing apoptosis of target cells
  16. 22. transcription factor that helps activate the expression of many pro-inflammatory genes