IMM Week 0-1 Crossword Puzzle Activity

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Across
  1. 4. Drug treatments for HIV infection.
  2. 6. A pore is formed in the pathogen membrane causing lysis.
  3. 11. A repeating pattern on microbes recognized by receptors on immune cells.
  4. 15. Helps differentiate immune cells from one another.
  5. 17. An adhesion molecule with the acronym CAM.
  6. 18. Very pro-inflammatory cytokine from macrophages and T cells.
  7. 19. CD4 and CD8 lymphocytes from the thymus.
  8. 20. These white blood cells contain multilobed nuclei and cytoplasmic granules.
  9. 21. These cell surface ligands bind lymphocytes and other leukocytes to certain cells.
  10. 22. Presents the peptide antigens to T cells.
  11. 24. HIV infection end-stage disease.
Down
  1. 1. Autoimmune regulator. This factor leads to the transcription of many hundred tissue-specific genes by subpopulation of epithelial cells in the thymus.
  2. 2. Natural killer cells use this mechanism to cause apoptosis to virus-infected or tumor cells.
  3. 3. Presents antigen to T cell receptors on T cells via major histocompatibility complex.
  4. 4. The name for the human major histocompatibility complex gene complex and proteins.
  5. 5. Antigen-presenting cells that present antigens like MHC to T cells.
  6. 7. A type of CD4+ T cell. Produce cytokines that activate macrophages. Promotes CD8+ responses against intracellular pathogens.
  7. 8. CD8+ cells that target and kill virally infected and tumor cells using apoptosis.
  8. 9. The receptor on immune and epithelial cells which finds and binds to microbes with PAMP.
  9. 10. Known as T-helper cells. Helps with adapted immunity.
  10. 12. Expressed on the surface of B cells.
  11. 13. Activation differentiates these cells into cytotoxic T lymphocytes.
  12. 14. Recognized by native antibodies or B cell receptors or an MHC presented peptide to T cell receptor.
  13. 16. An infection with the acronym HIV.
  14. 23. This is an immunoglobulin that plasma cells secrete