Immune control and Immunopathology of SARS-CoV-2

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Across
  1. 3. Inflammatory mediators responsible for cell-cell communication within the immune system
  2. 6. Severe complication of SARS-CoV-2 infection due to systemic release of proinflammatory mediators (two words)
  3. 7. ACE2 cleaves ... II
  4. 10. ... molecules present viral peptides to immune cells.
  5. 11. Severe complication of infection of lung epithelium
  6. 12. Virus-infected cells are detected and killed by CD8+ ... T cells.
  7. 14. The ultimate goal of the immune response is ... of infection.
  8. 15. Immune cell subset specialized in antigen-presentation during adaptive immune responses (two words)
  9. 16. Virus ... is the major contribution of antibodies in immune defense
  10. 18. cytokines with chemoattractant function
  11. 19. viral surface protein responsible for target cell infection (two words)
  12. 21. Reduced ACE2 expression in the circulatory system including heart and kidney results in ...
  13. 23. Clearance of antibody- or complement opsonized virus is accomplished via ...
Down
  1. 1. ... describes a potentially enhanced infectious capacity in presence of neutralizing antibodies
  2. 2. Differentiated B cell subsets specialized in antibody production
  3. 4. type I ... are produced by epithelial cells upon recognition of viral infection
  4. 5. Crucial components of the ... immune system are myeloid cells and the complement system.
  5. 8. Innate immune cells first recruited to the site of infection
  6. 9. soluble effector molecules of the adaptive/humoral immune response
  7. 13. pathway SARS-CoV-2 can activate the ... the pathway of complement system
  8. 17. pathologic consequence of platelet activation
  9. 20. Immunologic ... is a specific feature of the adaptive immune response.
  10. 22. The viral genome is composed of ...