Immune System Overview and Lymphocyte Development

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Across
  1. 6. B-cell developmental signals involving growth factors
  2. 8. Enzyme that binds to RSS
  3. 10. First name of Nobel Prize winner in 1987 for discovery of the genetic principal for generation of antibody diversity
  4. 16. Present in all tissues. They engulf and kill microbes
  5. 17. Development of blood cell types
  6. 19. Type of cell that secretes histamine
  7. 23. Circulatory organ of lymphatic system
  8. 24. circulates blood and differentiates into macrophages
  9. 27. Intestinal cell type that produces antimicrobal peptides
  10. 28. Histone modifications are necessary to ensure _______ exclusion
  11. 30. A self-reactive lymphocyte will undergo____ selection
Down
  1. 1. Expression of a functional B cell receptor is a type of _________ regulation
  2. 2. immunity dependent on personal history
  3. 3. Region responsible for antibody function
  4. 4. Complete set of unique antigen receptors in an individual
  5. 5. Cell types include B cells, T cells, and NK cells
  6. 7. this type of cell division results in a stem cell and a functional specialization cell
  7. 9. this type of vessel drains into the lymph nodes
  8. 11. This kind of Stem Cell creates Lymphoid Stem Cell
  9. 12. death of cells
  10. 13. region that binds to an antigen
  11. 14. Location of T-cell development
  12. 15. ______ region that heavy chain defines and defines function of the antibody
  13. 18. Target of adaptive immune responses
  14. 20. bone marrow is where b-cell and NK cells ____
  15. 21. B and T cells reside in _____ nodes
  16. 22. Recognizes native antigen
  17. 25. Recognizes short peptide fragments
  18. 26. Disease resulting from the loss of all lymphocytes
  19. 29. Immunity that is genetically encoded in stem cells