immunology

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Across
  1. 3. : cells: Subset of CD4+ T cells characterized by the cytokines they produce, including IL-4; involved in stimulating B cells to produce IgE antibody against helminths.
  2. 4. immunoglobulin secreted by plasma cells
  3. 8. immunity adaptive immune responses in which there is a major role
  4. 10. : Toll-like receptor, a family of pattern recognition receptors present on many leukocytes and epithelial cells that recognize PAMPs on pathogens and help initiate immune responses.
  5. 15. lectin a soluble acute phase response protein that can bind mannose on pathogens; can activate the lectin pathway of complement and acts as an opsonin.
  6. 18. Cluster of differentiation
  7. 19. : cells: Subset of CD4+ T cells characterized by the cytokines they produce, including IFN-gamma involved in fully activating macrophages, and IL-2 involved in promoting CTL responses against intracellular pathogens.
  8. 21. Antibody-dependent cellular cytotoxicity
  9. 23. Family names of chemokines
  10. 24. Cells: A type of APC that presents antigen in the context of MHC to T cells
  11. 26. : Pathogen-associated molecular patterns, repeating molecular patterns on microbes that are recognized by PRRs on immune cells.
  12. 28. Systemic lupus erythematosus, an autoimmune disease where autoantibodies (against DNA, RNA, and proteins associated with nucleic acids) form immune complexes.
Down
  1. 1. : Immunoreceptor tyrosine-based activation motifs, amino acid sequence in cytoplasmic domains of membrane receptors involved in signal transductio : Lipopolysaccharide, a cell wall component of gram-negative bacteria which TLR-4 can bind on macrophages and dendritic cells.
  2. 2. effector T cells
  3. 5. : Regulatory CD4+ T cells, regulatory T cells: a T cell subset that is responsible for suppressing or limiting immune responses.
  4. 6. : T-cell receptor, the antigen receptor on T cells.
  5. 7. : Interleukin, general designation of many of the different cytokines, chemical messengers secreted by immune cells that help in their communication with other cells.
  6. 9. : A cytokine produced by effector CD4+ TH1 cells, CD8+ T cells, and NK cells that plays a role in inducing TH1 differentiation and fully activating macrophages.
  7. 11. : Polymorphonuclear leukocytes, white blood cells with multi-lobed nuclei and cytoplasmic granules.
  8. 12. : Recombination signal sequences, short DNA sequences flanking Ig and TCR V, D, and J gene segments that serve as the binding sites for the RAG complex allowing Ig and TCR gene rearrangement (somatic recombination).
  9. 13. Surface immunoglobulin, an immunoglobulin that is expressed on B cell surface.
  10. 14. : Immunoglobulin, protein family to which antibodies and B-cell receptors belong.
  11. 16. : Nuclear factor of activated T cells, a key transcription factor that is required to bind to the IL-2 promoter to cause IL-2 transcription.
  12. 17. : Immune response.
  13. 18. T cells: T cells that express the CD4 protein on their surface and play a key role in the immune response. CD4 T cells: T cells that have previously encountered an antigen and have developed a memory response to it.
  14. 20. : Major histocompatibility complex, designation for a family of cell surface molecules involved in the presentation of peptide antigens to T cells.
  15. 21. Acquired immune deficiency syndrome
  16. 22. a molecule that is recognized in native (original) structure by antibodies or
  17. 25. : cells: Large granular lymphocytes that serve as an innate effector cell by inducing apoptosis of target cells.
  18. 27. Membrane attack complex, end product of the complement cascade that can kill pathogens directly by forming a pore in pathogen membrane leading to lysis.