Immunology Acronym Activity

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Across
  1. 3. IL; general designation for different cytokines & chemical messengers secreted by immune cells
  2. 5. Human leukocyte antigen; name of MHC gene complex and proteins in humans
  3. 8. T-cell receptor; the antigen receptor on T-cells
  4. 9. Ag; a molecule recognized by Ab or BCR and is presented by MHC molecules to TCRs
  5. 12. leukocytes PMN; WBCs with multi-lobed nuclei and cytoplasmic granules
  6. 14. Tumor necrosis factor; a cytokine produced by macrophages and T-cells that is highly pro-inflammatory
  7. 16. Pathogen associated molecular patterns; repeated molecular patterns on microbes
  8. 18. T-lymphocytes CTL; CD8+ T-cells with the function of targeting and killing virally infected cells by apoptosis
  9. 19. Cluster of differentiation; cell-surface molecules on immune cells that help differentiate one immune cell from another
  10. 20. C-reactive protein
  11. 21. Major histocompatibility complex; Family of cell surface molecules that present antigens to T-cells
  12. 24. Human immunodeficiency virus
  13. 25. Ab; Immunoglobulin secreted by plasma cells
  14. 26. Recognize PAMPs on pathogens and help initiate immune response
  15. 27. End stage of disease in HIV infection
Down
  1. 1. Pattern recognition receptors; receptors on immune cells that bind to PAMPs on microbes
  2. 2. LPS; a cell wall component of gram negative bacteria which can be bound by TLR-4 on macrophages and dendritic cells
  3. 3. Ig; protein family to which antibodies and b-cell receptors belong
  4. 4. Subset of CD4+ T-cells that produce cytokines to stimulate B-cells to produce antibodies
  5. 5. Highly active anti-retroviral therapy; a multiple drug therapy treatment for HIV infection
  6. 6. surface immunoglobulin; an immunoglobulin expressed on B-cell surface
  7. 7. Thymus derived lymphocyte comprised of two subsets: CD4 T-cells and CD8 T-cells
  8. 10. Cell-mediated immunity; adaptive immune responses mainly due to effector T-cells
  9. 11. Regulatory CD4+ T-cells responsible for suppressing immune responses
  10. 13. Natural killer cell; large granular lymphocyte that induce apoptosis of compromised cell
  11. 15. Presents antigen via MHC molecules to T-cell receptors
  12. 17. Membrane attack complex; end product of the Complement cascade that kills pathogens directly by forming a pore in pathogen membrane leading to lysis
  13. 18. Cell adhesion molecule
  14. 22. Member of TNF receptor family expressed on certain cells allowing for them to be killed by cells expressing Fas ligand
  15. 23. T-cell that express co-receptor protein CD4, which plays a role in adaptive immunity
  16. 27. Antibody dependent cellular cytotoxicity; mechanism by which NK cells induce apoptosis