Immunology Acronyms

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Across
  1. 1. the regions of the antigen binding loops of Ig molecules, antibodies and Tcell receptors that come into contact with antigen
  2. 3. repeating molecular patterns on microbes that are recognized by PRRs on immune cells
  3. 4. designation for a family of cell surface molecules involved in the presentation of peptide antigens to Tcells
  4. 6. a transcription factor that causes several hundred tissue-specific genes to be transcribed by a subpopulation of epithelial cells in the thymus
  5. 7. adaptive immune respones in which there is a major role for effector Tcells
  6. 9. amino acid sequence in cytoplasmic domains of membrane receptors involved in signal transduction
  7. 13. a cytokine produced by macrophages and Tcells that is highly pro-inflammatory
  8. 16. end product of complement cascade that can kill pathogens directly by forming a pore in pathogen membrane leading to lysis
  9. 17. transcription factor expressed in Treg cells that is needed for Treg cell function
  10. 20. large granular lymphocyte that serves as an innate effector cell by inducing apoptosis of targeted infected cells or of cancer cells
  11. 22. short DNA sequences flanking Ig and TCR V, D & J gene segments that serve as the binding sites for the RAG complex, allowing Ig and TCR gene rearrangement
  12. 24. the Ag receptor on Tcells
  13. 25. lymphocyte that upon activation can differentiate into plasma cells secreting antibody molecules of memory cells
Down
  1. 1. acute phase protein that binds to phosphocholine, a constituent of certain bacteria, that can trigger complement activation and acts as an opsonin
  2. 2. A cell that is able to present antigen via MHC molecules to Tcell receptors on Tcells
  3. 5. multiple drug treatment for HIV infection
  4. 8. family name for cytokines that help resist viral infections
  5. 9. Cells surface ligands for the leukocyte integrins; critical in binding of lymphocytes and other leukocytes to certain cells
  6. 10. a mechanism NK cells use to induce apoptosis in virally infected or tumor cells
  7. 11. an immunoglobulin that is expressed on Bcell surfaces
  8. 12. general designation of many of the different cytokines, chemical messengers secreted by immune cells that help their communication with other cells
  9. 13. thymus derived lymphocyte that are comprised of 2 different subsets CD4 & CD8
  10. 14. member of TNF receptor family expressed on certain cells that make them susceptible to being killed by cells expressing this ligand
  11. 15. receptors on immune cells and epithelial cells that recognize and bind to PAMPs on microbes
  12. 17. part of an antibody responsible for antigen binding
  13. 18. white blood cells with multi-lobed nuclei and cytoplasmic granules
  14. 19. a type of APC that presents antigens in the context of MHC to Tcells
  15. 21. a cell wall component of gram negative bacteria which can be bound by TLR4 on macrophages and dendritic cells
  16. 23. autoimmune disease where autoantibodies (against DNA, RNA & proteins associated with nucleic acids) form immune complexes
  17. 24. a family of PRR present on many leukocytes and epithelial cells that recognize PAMPs on pathogens and help initiate immune response
  18. 26. designation for specific cell-surface molecules on immune cells that help differentiate one immune cell from another