Immunology Acronyms

Across

3. member of TNF receptor family expressed on certain cells that makes them susceptible to being killed by cells expressing the Fas ligand
5. soluble acute phase response protein that can bind mannose on pathogens; can activate the lectin pathway of Complement and acts as an opsonin
6. family name for cytokines that help cells to resist viral infections; type 1 interferons include IFN-alpha and IFN-beta, as distinguished from IFN-gamma.
7. a T cell subset that is responsible for suppressing or limiting immune responses
8. acute phase protein that binds to phosphocholine, a constituent of certain bacteria, that can trigger Complement activation and acts as an opsonin
9. a transcription factor that causes several hundred tissue-specific genes to be transcribed by a subpopulation of epithelial cells in the thymus
10. protein family to which antibodies and B-cell receptors belong
11. the Ag receptor on T cells
13. cells surface ligands for the leukocyte integrins; critical in binding of lymphocytes and other leukocytes to certain cells
16. a cell that is able to present antigen via MHC molecules to T cell receptors on T cells
17. designation for a family of cell surface molecules involved in the presentation of peptide antigens to T cells
20. multiple drug treatment for HIV infection
22. immunoglobulin secreted by plasma cells
23. the part of an antibody (that can be isolated by protease digestion) responsible for antigen binding, consisting of the light chain and amino-terminal half of the heavy chain disulfide-bonded together
25. designation for specific cell-surface molecules on immune cells that help to differentiate one immune cell from another
26. CD8+ T cells with the effector function of targeting and killing virally infected cells and tumor cells by apoptosis
28. short DNA sequences flanking Ig and TCR V, D and J gene segments that serve as the binding sites for the RAG complex, allowing Ig and TCR gene rearrangement (somatic recombination)
30. a type of APC that presents antigen in the context of MHC to T cells
31. repeating molecular patterns on microbes that are recognized by PRRs on immune cells

Down

1. white blood cells with multi-lobed nuclei and cytoplasmic granules
2. general designation of many of the different cytokines, chemical messengers secreted by immune cells that help in their communication with other cells
4. an immunoglobulin that is expressed on B cell surface
7. a family of Pattern Recognition Receptors present on many leukocytes and epithelial cells that recognize PAMPs on pathogens and help initiate immune responses
8. the regions of the antigen binding loops of Ig molecules, antibodies and T cell receptors that come into contact with antigen
9. a molecule that is recognized in native (original) structure by antibodies or B cell receptor, or a peptide that is presented by MHC molecules to T cell receptor
10. immune response
12. adaptive immune responses in which there is a major role for effector T cells
14. Cell adhesion molecule
15. end product of the Complement cascade that can kill pathogens directly by forming a pore in pathogen membrane leading to lysis
18. name of MHC gene complex and proteins in humans
19. receptors on immune cells and epithelial cells that recognize and bind to PAMPs on microbes
21. the end stage of disease in HIV infection
22. a mechanism NK cells use to induce apoptosis in virally infected cells or tumor cells
23. transcription factor expressed in Treg cells that is needed for Treg cell function
24. sIg on B cells that binds Ag and transmits signal 1 to activate B cells.
27. a cell wall component of gram negative bacteria which can be bound by TLR-4 on macrophages and dendritic cells
29. autoimmune disease where autoantibodies (against DNA, RNA, and proteins associated with nucleic acids) form immune complexes