Immunology Acronyms

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Across
  1. 2. CD8+ T cells with the effector function of targeting and killing virally infected cells and tumor cells by apoptosis
  2. 4. general designation of many of the different cytokines which are chemical messengers secreted by immune cells that help in their communication with other cells
  3. 7. white blood cells with multi-lobed nuclei and cytoplasmic granules
  4. 8. immunoglobulin secreted by plasma cells
  5. 11. cells surface ligands for the leukocyte integrins; Critical in binding of lymphocytes and other leukocytes to certain cells
  6. 12. the regions of the antigen binding loops of Ig molecules, antibodies and T cell receptors that come into contact with antigen
  7. 14. a family of Pattern Recognition Receptors present on many leukocytes and epithelial cells that recognize PAMPs on pathogens and help initiate immune responses
  8. 15. a cell that is able to present antigen via MHC molecules to T cell receptors on T cells
  9. 16. amino acid sequence in cytoplasmic domains of membrane receptors involved in signal transduction
  10. 18. short DNA sequences flanking Ig and TCR V D and J gene segments that serve as the binding sites for the RAG complex allowing Ig and TCR gene rearrangement
  11. 20. a molecule that is recognized in native (original) structure by antibodies or B cell receptor, or a peptide that is presented by MHC molecules to T cell receptor
  12. 21. designation for specific cell-surface molecules on immune cells that help to differentiate one immune cell from another
  13. 22. a type of APC that presents antigen in the context of MHC to T cells
  14. 23. acute phase protein that binds to phosphocholine that can trigger Complement activation and acts as an opsonin
  15. 25. end product of the Complement cascade that can kill pathogens directly by forming a pore in pathogen membrane leading to lysis
  16. 26. Fragment with antigen binding: the part of an antibody (that can be isolated by protease digestion) responsible for antigen binding consisting of the light chain and amino-terminal half of the heavy chain disulfide-bonded together
Down
  1. 1. autoimmune disease where autoantibodies (against DNA, RNA, and proteins associated with nucleic acids) form immune complexes
  2. 2. adaptive immune responses in which there is a major role for effector T cells
  3. 3. name of MHC gene complex and proteins in humans
  4. 5. a cell wall component of gram negative bacteria which can be bound by TLR-4 on macrophages and dendritic cells
  5. 6. multiple drug treatment for HIV infection
  6. 9. sIg on B cells that binds Ag and transmits signal 1 to activate B cells.
  7. 10. receptors on immune cells and epithelial cells that recognize and bind to PAMPs on microbes
  8. 11. family name for cytokines that help cells to resist viral infections
  9. 13. Member of TNF receptor family expressed on certain cells that makes them susceptible to being killed by cells expressing the specific ligand
  10. 14. the Ag receptor on T cells
  11. 16. protein family to which antibodies and B-cell receptors belong
  12. 17. designation for a family of cell surface molecules involved in the presentation of peptide antigens to T cells
  13. 19. an immunoglobulin that is expressed on B cell surface
  14. 20. a mechanism NK cells use to induce apoptosis in virally infected cells or tumor cells
  15. 24. repeating molecular patterns on microbes that are recognized by PRRs on immune cells
  16. 25. soluble acute phase response protein that can bind mannose on pathogens; can activate the lectin pathway of Complement and acts as an opsonin