Immunology Acronyms

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Across
  1. 2. cells surface ligands for the leukocyte integrins; Critical in binding of lymphocytes and other leukocytes to certain cells
  2. 5. repeating molecular patterns on microbes that are recognized by PRRs on immune cells
  3. 7. a molecule that is recognized in native (original) structure by antibodies or B cell receptor, or a peptide that is presented by MHC molecules to T cell receptor
  4. 10. designation for specific cell-surface molecules on immune cells that help to differentiate one immune cell from another
  5. 12. a mechanism NK cells use to induce apoptosis in virally infected cells or tumor cells
  6. 13. adaptive immune responses in which there is a major role for effector T cells
  7. 15. an immunoglobulin that is expressed on B cell surface
  8. 16. a family of Pattern Recognition Receptors present on many leukocytes and epithelial cells that recognize PAMPs on pathogens and help initiate immune responses
  9. 19. a cell wall component of gram negative bacteria which can be bound by TLR-4 on macrophages and dendritic cells
  10. 23. general designation of many of the different cytokines which are chemical messengers secreted by immune cells that help in their communication with other cells
  11. 24. immunoglobulin secreted by plasma cells
  12. 25. Fragment with antigen binding: the part of an antibody (that can be isolated by protease digestion) responsible for antigen binding consisting of the light chain and amino-terminal half of the heavy chain disulfide-bonded together
  13. 26. end product of the Complement cascade that can kill pathogens directly by forming a pore in pathogen membrane leading to lysis
  14. 28. CD8+ T cells with the effector function of targeting and killing virally infected cells and tumor cells by apoptosis
  15. 29. family name for cytokines that help cells to resist viral infections
Down
  1. 1. name of MHC gene complex and proteins in humans
  2. 3. acute phase protein that binds to phosphocholine that can trigger Complement activation and acts as an opsonin
  3. 4. multiple drug treatment for HIV infection
  4. 6. autoimmune disease where autoantibodies (against DNA, RNA, and proteins associated with nucleic acids) form immune complexes
  5. 7. a cell that is able to present antigen via MHC molecules to T cell receptors on T cells
  6. 8. amino acid sequence in cytoplasmic domains of membrane receptors involved in signal transduction
  7. 9. protein family to which antibodies and B-cell receptors belong
  8. 11. a type of APC that presents antigen in the context of MHC to T cells
  9. 14. soluble acute phase response protein that can bind mannose on pathogens; can activate the lectin pathway of Complement and acts as an opsonin
  10. 17. short DNA sequences flanking Ig and TCR V D and J gene segments that serve as the binding sites for the RAG complex allowing Ig and TCR gene rearrangement
  11. 18. the Ag receptor on T cells
  12. 20. white blood cells with multi-lobed nuclei and cytoplasmic granules
  13. 21. receptors on immune cells and epithelial cells that recognize and bind to PAMPs on microbes
  14. 22. the regions of the antigen binding loops of Ig molecules, antibodies and T cell receptors that come into contact with antigen
  15. 26. designation for a family of cell surface molecules involved in the presentation of peptide antigens to T cells
  16. 27. sIg on B cells that binds Ag and transmits signal 1 to activate B cells.
  17. 30. Member of TNF receptor family expressed on certain cells that makes them susceptible to being killed by cells expressing the specific ligand