Immunology Acronyms

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Across
  1. 2. the Ag receptor on Tcells
  2. 3. end product of complement cascade that can kill pathogens directly by forming a pore in pathogen membrane leading to lysis
  3. 6. a type of APC that presents antigens in the context of MHC to Tcells
  4. 8. part of an antibody responsible for antigen binding
  5. 11. a family of PRR present on many leukocytes and epithelial cells that recognize PAMPs on pathogens and help initiate immune response
  6. 12. short DNA sequences flanking Ig and TCR V, D & J gene segments that serve as the binding sites for the RAG complex, allowing Ig and TCR gene rearrangement
  7. 13. general designation of many of the different cytokines, chemical messengers secreted by immune cells that help their communication with other cells
  8. 14. designation for a family of cell surface molecules involved in the presentation of peptide antigens to Tcells
  9. 18. a cell wall component of gram negative bacteria which can be bound by TLR4 on macrophages and dendritic cells
  10. 20. adaptive immune respones in which there is a major role for effector Tcells
  11. 21. repeating molecular patterns on microbes that are recognized by PRRs on immune cells
  12. 23. family name for cytokines that help resist viral infections
  13. 25. an immunoglobulin that is expressed on Bcell surfaces
  14. 26. large granular lymphocyte that serves as an innate effector cell by inducing apoptosis of targeted infected cells or of cancer cells
  15. 27. A cell that is able to present antigen via MHC molecules to Tcell receptors on Tcells
Down
  1. 1. Cells surface ligands for the leukocyte integrins; critical in binding of lymphocytes and other leukocytes to certain cells
  2. 4. designation for specific cell-surface molecules on immune cells that help differentiate one immune cell from another
  3. 5. multiple drug treatment for HIV infection
  4. 7. the regions of the antigen binding loops of Ig molecules, antibodies and Tcell receptors that come into contact with antigen
  5. 8. member of TNF receptor family expressed on certain cells that make them susceptible to being killed by cells expressing this ligand
  6. 9. lymphocyte that upon activation can differentiate into plasma cells secreting antibody molecules of memory cells
  7. 10. amino acid sequence in cytoplasmic domains of membrane receptors involved in signal transduction
  8. 15. acute phase protein that binds to phosphocholine, a constituent of certain bacteria, that can trigger complement activation and acts as an opsonin
  9. 16. thymus derived lymphocyte that are comprised of 2 different subsets CD4 & CD8
  10. 17. a transcription factor that causes several hundred tissue-specific genes to be transcribed by a subpopulation of epithelial cells in the thymus
  11. 19. white blood cells with multi-lobed nuclei and cytoplasmic granules
  12. 22. a mechanism NK cells use to induce apoptosis in virally infected or tumor cells
  13. 24. transcription factor expressed in Treg cells that is needed for Treg cell function
  14. 25. autoimmune disease where autoantibodies (against DNA, RNA & proteins associated with nucleic acids) form immune complexes