Immunology Exam #2 Crossword Puzzle

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Across
  1. 4. A process in which cells can consume their own intracellular proteins to digest into peptides they can use to display on their surface.
  2. 5. Class of antibody that is first activated from naive B cells.
  3. 8. Protein on the surface of CTLs that bind to a protein on the target cell to induce cellular apoptosis (two words).
  4. 11. Class of molecules that only bind to CD4.
  5. 12. Naive T cells that are exposed to ______ are induced to become regulatory T cells.
  6. 14. Class of antibody that protects mucosal surfaces.
  7. 17. CD4 and CD8 are examples of co-_____.
  8. 18. Class I MHC molecules that present protein fragments that come from inside the cell.
  9. 19. Protein inside a cell who's job it is to chop up and recycle other proteins into peptide fragments.
  10. 23. An example of mucosal-associated lymphoid tissues that function as secondary lymphoid organs (two words).
  11. 25. Class of antibody that causes allergies.
  12. 29. When many BCRs are brought close together, causing B cells to activate
  13. 31. Cells that produce IFNa and IFNb in response to viral attack are ______ dendritic cells.
  14. 32. Areas where B cells and T cells can enter through from the blood to get to secondary lymphoid organs are called the high ______ venule.
  15. 34. The _____ main function is to filter blood.
  16. 35. T cells that inhibit immune response (abbrev. name).
  17. 36. "Islands" in the secondary lymphoid organs that are rich with B cells contained by by a lose network of FDCs are called lymphoid _____.
  18. 37. Th2 helper T cells target ______ infections.
  19. 42. When B cells change the type of antibodies they produce (two words).
Down
  1. 1. When B cells become crosslinked on FDCs and they begin to proliferate, this area becomes the center of B cell development (two words).
  2. 2. External region of a transmembrane protein that binds to molecules.
  3. 3. FDCs produce a ______ called CXCL13 that attract naive B cells.
  4. 6. The first "exam" T cells must pass in order to continue on to becoming properly functioning T cells (two words).
  5. 7. The area where APCs and T cells come into contact through adhesion molecules is called the _____ synapse.
  6. 9. B7 protein on the surface of APCs that "plugs into" CD28 on a T cell surface is an example of co-_______.
  7. 10. Proteins that give organs their specific identity (two words).
  8. 13. Th17 helper T cells target ______ infections.
  9. 15. ______ proteins are proteins that help inhibit T cells as the infection is beginning to subside, such as VTLA-4 and PD-1.
  10. 16. B cells that undergo T cell-______ activation typically also undergo somatic hypermutation/class switching.
  11. 20. CTLs produce this component that triggers apoptosis (two words).
  12. 21. _____ selection eliminates T cells whos receptors recognize self antigens presented on MHC molecules.
  13. 22. A method in which T cells are eliminated after they have been restimulated several times during various viral infections (abbrev. name).
  14. 23. The part of the lymphnodes where T cells tend to accumulate.
  15. 24. Rearranged genes in a cell mutate to increase affinity of receptors for it's cognate antigen (two words).
  16. 26. Class II MHC molecules that present protein fragments that come from outside the cell.
  17. 27. Region where BCR binds to its antigen.
  18. 28. The part of the lymphnodes where B cells tend to accumulate.
  19. 30. Location in which T cells learn tolerance to self.
  20. 33. Process in which IgG antibodies create a a "bridge" between NK cells and it's target cell, making NK cells more effective killers (abbrev. name).
  21. 38. Virgin T cells are allowed to visit specific cites in the body due to _____ molecules.
  22. 39. The antigen that a B cell can recognize.
  23. 40. Class of molecules that only bind to CD8.
  24. 41. _____ selection eliminates T cells whos receptors cannot recognize self MHC molecules.