Immunology Exam #2 Review - Renee Myers

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Across
  1. 2. Regulatory T cell that protects from autoimmune disease
  2. 8. T cell that generally expresses the CD4 co-receptor (3 words - no abbreviations)
  3. 10. Antigen presenting cell that can "re-stimulate" experienced T cells, can be activated by IFN-g and DOESN'T travel to the lymph nodes (2 words)
  4. 13. Antibody that is highly effective at neutralizing viruses and fixing complement
  5. 14. These cut proteins into peptides in the cytoplasm
  6. 17. This helper T cell subset produces IL-17 and IL-21, and is activated by IL-6 and TGFb
  7. 18. This helper T cell subset produces IL-4, IL-5, and IL-13 and is activated by IL-4
  8. 19. The step of B cell maturation in which the rearranged genes can mutate to increase the average affinity of BCRs for their cognate antigen (2 words)
  9. 21. These cells are embedded in the regions of the secondary lymphoid organs, with the primary function of displaying antigen to B cells (3 words)
  10. 25. The step of B cell maturation in which the B cell changes the class of antibody it produces (2 words)
  11. 26. Region of the cognate antigen that a BCR actually binds to
  12. 28. Regulatory T cell that dampens the immune response (abbreviation)
  13. 30. A B cell that is an "antibody factory"
  14. 31. Combination of gene segments that will produce a full-length Hc protein (2 words)
Down
  1. 1. Fragments of proteins manufactured by the cell; displayed by class I MHC molecules (2 words)
  2. 3. T cell that generally expresses the CD8 co-receptor (3 words - no abbreviations)
  3. 4. Fully mature Th cells that help B cells switch classes or undergo somatic hypermution through the interaction between CD40L and CD40 proteins(4 words)
  4. 5. Antigen presenting cell that can activate virgin T cells; these cells can be activated by TNF and travel to lymph nodes to present antigen (2 words)
  5. 6. Protein that can bind to cell membranes and drill holes in them
  6. 7. Antibody that guards the mucosal surfaces of the body
  7. 9. Antigens that come from outside the cell; displayed by class II MHC molecules (2 words)
  8. 11. "Doorway" through which B and T cells enter the secondary lymphoid organs from the blood (3 words, abbreviation)
  9. 12. B cells that have encountered their cognate antigen and have been activated (3 words)
  10. 15. Antigen presenting cell that is not used during initial stages of infection, but can quickly activate helper T cells by concentrating antigen for presentation
  11. 16. Antibody that activates the classical (antibody-dependent) pathway; first antibody made by B cells
  12. 20. Antibody that causes allergies and anaphylactic shock
  13. 22. This helper T cell subset produces TNF, IFN-g, and IL-2 and is activated by IL-12
  14. 23. Protein that prevents the class II MHC molecule from picking up other peptides in the ER AND guides class II MHC molecules through the Golgi apparatus (2 words)
  15. 24. These transporter proteins carry proteasomes across the membrane of the endoplasmic reticulum
  16. 27. This helper T cell subset is unbiased and commits to a subset based on the cytokine environment
  17. 29. Enzyme that triggers cells to commit suicide by apoptosis once it enters the cytoplasm of the target cell (2 words)