Immunology Puzzle

12345678910111213141516171819202122232425262728293031323334
Across
  1. 2. receptors on immune cells and epithelial cells that recognize and bind to PAMPs on microbes
  2. 4. white blood cells with multi-lobed nuclei and cytoplasmic granules
  3. 5. designation for a family of cell surface molecules involved in the presentation of peptide antigens to T cells
  4. 10. multiple drug treatment for HIV infection
  5. 16. designation for specific cell-surface molecules on immune cells that help to differentiate one immune cell from another
  6. 17. transcription factor that helps activate the expression of many pro-inflammatory genes
  7. 19. a cell wall component of gram negative bacteria which can be bound by TLR-4 on macrophages and dendritic cells
  8. 21. autoimmune disease where autoantibodies (against DNA, RNA, and proteins associated with nucleic acids) form immune complexes
  9. 25. immunoglobulin secreted by plasma cells
  10. 26. large granular lymphocyte that serves as an innate effector cell by inducing apoptosis of target cells (virally infected cells or tumor cells)
  11. 28. lymphocyte that upon activation can differentiate into plasma cells secreting antibody molecules or B memory cells
  12. 29. soluble acute phase response protein that can bind mannose on pathogens; can activate the lectin pathway of Complement and acts as an opsonin
  13. 30. a cytokine produced by macrophages and T cells that is highly pro-inflammatory
  14. 31. the two genes essential for Ig and TCR gene rearrangement; their gene products (RAG-1 & RAG-2) comprise the RAG complex
  15. 32. thymus-derived lymphocyte that are comprised of two different subsets, CD4 T cells and CD8 T cells
  16. 33. a transcription factor that causes several hundred tissue-specific genes to be transcribed by a subpopulation of epithelial cells in the thymus
  17. 34. name of MHC gene complex and proteins in humans
Down
  1. 1. a type of APC that presents antigen in the context of MHC to T cells
  2. 3. general designation of many of the different cytokines, chemical messengers secreted by immune cells that help in their communication with other cells
  3. 6. large mononuclear phagocyte that takes residence in many different tissues and organs and contributes to innate immune responses and can act as an effector cell in adaptive immune responses
  4. 7. adaptive immune responses in which there is a major role for effector T cells
  5. 8. the part of an antibody that consists of the carboxy terminal halves of the two heavy chains disulfide-bonded to each other; the Fc region of an antibody is where Fc receptors bind, and so is responsible for antibody effector function (after antigen binding occurs)
  6. 9. Human immunodeficiency virus
  7. 11. an immunoglobulin that is expressed on B cell surface
  8. 12. acute phase protein that binds to phosphocholine, a constituent of certain bacteria, that can trigger Complement activation and acts as an opsonin
  9. 13. CD8+ T cells with the effector function of targeting and killing virally infected cells and tumor cells by apoptosis
  10. 14. a key transcription factor that is required to bind to the IL-2 promoter to cause IL-2 transcription
  11. 15. the regions of the antigen binding loops of Ig molecules, antibodies and T cell receptors that come into contact with antigen
  12. 18. a molecule that is recognized in native (original) structure by antibodies or B cell receptor, or a peptide that is presented by MHC molecules to T cell receptor
  13. 20. short DNA sequences flanking Ig and TCR V, D and J gene segments that serve as the binding sites for the RAG complex, allowing Ig and TCR gene rearrangement (somatic recombination)
  14. 22. a family of Pattern Recognition Receptors present on many leukocytes and epithelial cells that recognize PAMPs on pathogens and help initiate immune responses
  15. 23. end product of the Complement cascade that can kill pathogens directly by forming a pore in pathogen membrane leading to lysis
  16. 24. family name for cytokines that help cells to resist viral infections; type 1 interferons include IFN-alpha and IFN-beta, as distinguished from IFN-gamma.
  17. 27. the Ag receptor on T cells