Immunology Terminology

1234567891011121314151617181920212223242526272829303132
Across
  1. 1. receptor, the Ag receptor on T cells
  2. 4. Member of TNF receptor family expressed on certain cells that makes them
  3. 5. a peptide that is presented by MHC molecules to T cell receptor
  4. 8. Transcription factor expressed in Treg cells that is needed for Treg cell function
  5. 10. receptor, a family of Pattern Recognition Receptors present on many leukocytes and epithelial cells that recognize PAMPs on pathogens and help initiate immune responses
  6. 11. recognition receptors, receptors on immune cells and epithelial cells that recognize and bind to PAMPs on microbes
  7. 12. immunoglobulin secreted by plasma cells
  8. 13. the regions of the antigen binding loops of Ig molecules, antibodies and T cell receptors that come into contact with antigen
  9. 15. T cells that express the co-receptor protein CD8 which upon activation differentiate into cytotoxic T lymphocytes (CTLs)
  10. 16. cell, a type of APC that presents antigen in the context of MHC to T cells
  11. 17. adhesion molecules, cells surface ligands for the leukocyte integrins; Critical in binding of lymphocytes and other leukocytes to certain cells
  12. 19. acute phase protein that binds to phosphocholine that can trigger Complement activation and acts as an opsonin
  13. 21. Human immunodeficiency virus
  14. 23. leukocyte antigen, name of MHC gene complex and proteins in humans
  15. 24. a molecule that is recognized in native (original) structure by antibodies or
  16. 26. a cytokine produced by macrophages and T cells that is highly pro-inflammatory
  17. 27. to being killed by cells expressing the Fas ligand
  18. 30. leukocytes, white blood cells with multi-lobed nuclei and cytoplasmic granules
Down
  1. 2. a cell wall component of gram negative bacteria which can be bound by TLR-4 on macrophages and dendritic cells
  2. 3. transcription factor that helps activate the expression of many pro-inflammatory genes
  3. 6. T cells which upon activation differentiate into distinct Thelper phenotypes with different roles in adaptive immunity
  4. 7. CD8+ T cells with the effector function of targeting and killing virally infected cells and tumor cells by apoptosis
  5. 9. attack complex, end product of the Complement cascade that can kill pathogens directly by forming a pore in pathogen membrane leading to lysis
  6. 14. general designation of many of the different cytokines, chemical messengers secreted by immune cells that help in their communication with other cells
  7. 18. a cell that is able to present antigen via MHC molecules to T cell receptors on T cells
  8. 20. protein family to which antibodies and B-cell receptors belong
  9. 22. family name for cytokines that help cells to resist viral infections; type 1 include IFN-alpha and IFN-beta, as distinguished from IFN-gamma.
  10. 25. a transcription factor that causes several hundred tissue-specific genes to be transcribed by a subpopulation of epithelial cells in the thymus
  11. 28. a lymphocyte that upon activation can differentiate into plasma cells secreting antibody molecules or memory cells
  12. 29. killer cell, large granular lymphocyte that serves as an innate effector cell by inducing apoptosis of target cells (virally infected cells or tumor cells)
  13. 31. histocompatibility complex, designation for a family of cell surface molecules involved in the presentation of peptide antigens to T cells
  14. 32. Cell adhesion molecule