Immunology Terms

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Across
  1. 3. molecule that is recognized in native structure by antibodies or B cell receptor, or a peptide that is presented by MHC molecules to T cell receptor
  2. 4. large mononuclear phagocyte that takes residence in many different tissues and organs, and contributes to innate immune resposnses
  3. 6. protein family to which antibodies and B cell receptors belong
  4. 7. multiple drug treatment for HIV infection
  5. 8. cell surface ligands for the leukocyte integrins
  6. 9. a type of cell that is able to present antigen via MHC molecules to T cell receptors on T cells
  7. 11. transcription factor expressed in Treg cells that is needed for T reg cell function
  8. 12. immunoglobulin secreted by plasma cells
  9. 15. large granular lymphocyte that serves as an innate effector cell by inducing apoptosis of target cells
  10. 18. type of adaptive immunity in which there is a major role for effector T cells
  11. 20. end product of the complement cascade that can kill pathogens directly by forming a pore in pathogen membrane leading to lysis
  12. 25. the antigen receptor on T cells
  13. 26. subset of CD4+ T cells that are involved in fully activating macrophages and promoting CTL responses against intracellular pathogens
  14. 27. cell wall component of gram negative bacteria which can be bound by TLR-4 on macrophages and dendritic cells
  15. 28. a transcription factor that causes several hundred tissue-specific genes to be transcribed by a subpopulation of epithelial cells in the thymus
  16. 30. a type of immunoglobulin that is expressed on B cell surface
Down
  1. 1. pathogen associated molecular patterns
  2. 2. type of APC that presents antigen in the context of MHC to T cells
  3. 5. type of leukocyte with multi-lobed nuclei and cytoplasmic granules
  4. 9. acquired immune deficiency syndrome: the end stage of disease in HIV infection
  5. 10. cell adhesion molecule
  6. 13. type of pattern recognition receptors present of leukocytes and epithelial cells that recognize PAMP's on pathogens
  7. 14. acute phase protein that binds to phosphocholine, and can trigger complement activation, and acts as an opsonin
  8. 16. family name for cytokines that helps cells to resist viral infections
  9. 17. general designation of many of the different cytokines
  10. 18. type of CD8+ T lymphocyte with the effector function of targeting and killing virally infected cells and tumor cells via apoptosis
  11. 19. thymus-derived lymphocyte that are comprimised of two different subsets (CD4 and CD8)
  12. 21. soluble acute phase response protein that can bind mannose on pathogens and can activate the lectin pathway of Complement
  13. 22. a mechanism NK cells use to induce apoptosis in virally infected cells or tumor cells
  14. 23. receptors on immune cells and epithelial cells that recognize and bind to PAMP's on microbes
  15. 24. subset of CD4+ T cells that are involved in stimulating B cells to produce antibody against extracellular pathogens
  16. 29. B lymphocyte that upon activation can differentiate into plasma cells secreting antibody molecules or B memory cells