Immunology Terms

4. Acute phase protein that binds to phosphocholine, a constituent of certain bacteria, can trigger complement activation and acts as an opsonin
5. Large mononuclear phagocyte that takes residence in many different tissues and organs and contributes to innate immune responses and can act as an effector cell in adaptive immune responses
6. Repeating molecular patterns on microbes that are recognized by PRRs on immune cells
8. Cells surface ligands for the leukocyte integrins; critical in binding of lymphocytes and other leukocytes to certain cells
9. Large granular lymphocyte that serves as an innate effector cell by inducing apoptosis of target cells
12. A mechanism NK cells use to induce apoptosis in virally infected cells or tumor cells
13. General designation of many of the different cytokines
15. Amino acid sequence in cytoplasmic domains of membrane receptors involved in signal transduction (tyrosine-based)
16. Family name for cytokines that help cells to resist viral infections
17. Member of TNF receptor family expressed on certain cells that makes them susceptible to being killed by cells expressing its ligand
18. A type of APC that presents antigen in the context of MHC to T cells
21. Regulatory CD4+ T cells, a T cell subset that is responsible for suppressing or limiting immune responses
23. Characteristic of leukocytes; WBCs with multi-lobed nuclei and cytoplasmic granules
24. Immunoglobulin secreted by plasma cells

1. The part of antibody that consists of the carboxy terminal halves of the two heavy chains disulfide-bonded to each other
2. A cell wall component of gram negative bacteria which can be bound by TLR-4 on macrophages and dendritic cells
3. Name of MHC gene complex and proteins in humans
7. A transcription factor that causes several hundred tissue-specific genes to be transcribed by a subpopulation of epithelial cells in the thymus
10. Cytokine produced by effector CD4+ T cells, CD8+ T cells, NK cells; primary actions are to act with IL-12 to induce TH1 differentiation & to fully activate macrophages
11. Family name for chemokines, chemicals that are a sub-class of cytokines with cell-attractant properties
12. A molecule that is recognized in native (original) structure by antibodies or B cell receptors, or a peptide that is presented by MHC molecules to T cell receptor
14. A family of pattern recognition receptors present on many leukocytes and epithelial cells that recognize PAMPs on pathogens and help initiate immune responses
19. Cytokine produced by macrophages and T cells that is highly pro-inflammatory
20. Lymphocyte that upon activation can differentiate into plasma cells secreting antibody molecules or respective memory cells
22. Highly active anti-retroviral therapy: multiple drug treatment for HIV infection