Immunology Vocabulary

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Across
  1. 6. slg on B cells that binds Ag and transmits signal 1 to activate B cells
  2. 9. chemical messengers secreted by immune cells that help in their communication with other cells
  3. 11. abbreviation for name of MHC gene complex and proteins in humans
  4. 15. family of pattern recognition receptors present on leukocytes and epithelial cells that recognize PAMPs on pathogens and help initiate immune response
  5. 16. abbreviation for a cell that is able to present antigen via MHC molecules to T cell receptors on T cells
  6. 17. one of two recombination activating genes which are essential for Ig and TCR gene rearrangement
  7. 18. family name for cytokines that help cells to resist viral infections
  8. 19. T cells that express the co-receptor protein which upon activation differentiate into cytotoxic T lymphocytes
  9. 20. immunoglobulin secreted by plasma cells
  10. 21. protein family to which antibodies and B-cell receptors belong
  11. 22. abbreviation for the Ag receptor on T cells
  12. 23. abbreviation for cell adhesion molecule
  13. 24. an abbreviation for a mechanism NK cells use to induce apoptosis in virally infected cells or tumor cells
  14. 25. abbreviation for the designation of a family of cell surface molecules involved in presentation of peptide antigens to T cells
  15. 26. family name of chemokines, chemicals that are a sub-class of cytokines with cell-attractant properties
  16. 28. thymus-derived lymphocytes that are comprise of two different subsets, CD4 T cells and CD8 T cells
  17. 29. large granular lymphocyte that serves as innate effector cell by inducing apoptosis of virally infected cells and tumor cells
Down
  1. 1. large mononuclear phagocyte that contributes to innate immune responses; can act as effector cell in adaptive immune responses
  2. 2. B lymphocyte that upon activation can differentiate into plasma cells secreting antibody molecules or B memory cells
  3. 3. an immunoglobulin that is expressed on B cell surface
  4. 4. abbreviation for a transcription factor that causes several hundred tissue-specific genes to be transcribed by a subpopulation of epithelial cells in the thymus
  5. 5. abbreviation for white blood cells with multi-lobed nuclei and cytoplasmic granules
  6. 7. T cells that express the co-receptor protein which upon activation differentiate into distinct T-helper phenotypes
  7. 8. cell wall component of gram negative bacteria which can be bound by TLR-4 on macrophages and dendritic cells
  8. 10. transcription factor that helps activate the expression of many pro-inflammatory genes
  9. 12. type of APC that presents antigen in the context of MHC to T cells
  10. 13. abbreviation for receptors on immune cells and epithelial cells that recognize and bind to PAMPs on microbes
  11. 14. abbreviation for an autoimmune disease where autoantibodies form immune complexes
  12. 15. regulatory CD4+ T cells: a T cell subset that is responsible for suppressing or limiting immune responses
  13. 27. recognized in native structure by antibodies or B cell receptor; a peptide that is presented by MHC molecules to T cell receptor