Infectious Diseases Affecting the Cardiovascular & Lymphatic Systems

123456789101112131415161718
Across
  1. 4. A serious condition in which bacteria are actively multiplying in the bloodstream, triggering a dangerous systemic immune response. Distinct from bacteremia, which only implies presence.
  2. 7. Accumulations of bacteria on heart valves that impair valve function and can break off to form emboli that block vital organs.
  3. 10. A life-threatening condition resulting from cascading immune responses to septicemia, characterized by a drastic drop in blood pressure and up to 50% mortality rate.
  4. 11. The characteristic bullseye rash appearing at the site of a tick bite in early Lyme disease, consisting of a raised reddish ring that gradually spreads outward with a pale central region.
  5. 12. A spirochete bacteium that causes Lyme disease. Classified as gram-negative due to an outer membrane but uniquely lacks LPS/endotoxin, and evades the immune system by changing its surface antigens.
  6. 14. Red, painless spots on the palms and soles caused by embolic blockages. Found in the presence of endocarditis.
  7. 15. A slower-onset form of endocarditis that almost always follows prior valve damage or congenital malformation, commonly caused by low-pathogenicity oral bacterial such as alpha-hemolytic streptococci.
  8. 16. A tick-borne bacterial infection caused by Rickettsia rickettsi, characterized by a distinctive spotted rash starting at the wrists, forearms, and ankles, most common in the southeastern United States.
  9. 18. Viral infections caused by ssRNA enveloped viruses that infect the blood and lymphatics, causing capillary fragility, disruption of blood clotting, and internal hemorrhaging.
Down
  1. 1. The presence of bacteria in the blood, without necessarily implying active multiplication.
  2. 2. An ssRNA virus closely related to Ebola, endemic to Africa, causing severe hemorrhagic fever with an average fatality rate of approximately 50%.
  3. 3. A rapidly progressing form of endocarditis most often caused by Staphylococcus aureus, in which bacteria colonize normal heart valves, form vegetations, and can cause emboli or cardiac failure.
  4. 5. A progressive tick-borne illness caused by Borrelia burgdorferi, presenting with a bullseye rash (erythema migrans) and potentially avancing to cardiac, neurological, and arthritic complications if untreated.
  5. 6. Inflammation and infection of the endocardium, most often involving the heart valves, caused by bacterial colonization that can form vegetations and lead to cardiac malfunction.
  6. 8. An ssRNA virus endemic to Africa that causes extreme capillary fragility, bleeding from orifices, and has an average fatality rate of around 50%. Bats are thought to be its natural reservoir.
  7. 9. A bacterial infection caused by Bartonella henselae, transmitted to humans through cat scratches or bites, presenting with papules at the inoculation site and primarily affecting children.
  8. 13. Small, painful nodes on finger and toe pads caused by immune complex-mediated vessel inflammation. Found in the presence of endocarditis.
  9. 17. The presence of viruses in the bloodstream.