Innate Immune System

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Across
  1. 2. abbreviation for Pattern Recognition Receptors. Found on innated immune cells.
  2. 3. vertebrates only, slower response. B cells and T cells.
  3. 5. provide innate defense, interferes with viruses and helps activate macrophages.
  4. 6. both vertebrates and invertebrates share these: barriers, phagocytosis, antimicrobial peptides.
  5. 10. release antimicrobial peptides in the hemolymph of invertebrates.
  6. 12. involved in allergic and anti-helminth responses.
  7. 14. abbreviation for Pattern Associated Molecular Patterns. Found on potential pathogens.
  8. 15. consists of about 30 proteins activated by substances on microbe surface. When activated can lead to lysis of invading microbe.
  9. 16. aka antigen presenting cells. "Long arms" allow them to capture and present antigens to the immune system.
Down
  1. 1. unique only to this group. NK cells, interferons, the inflammatory response.
  2. 4. abbreviation for toll like response receptors, a form or PRRs, that phagocytize pathogens.
  3. 7. Natural Killer Cells; innate defense of vertebrates. Lymphocyte that detects abnormal cells and release chemicals directly leading to pathogen death.
  4. 8. both vertebrates and invertebrates, rapid response. Physical barriers and internal defenses.
  5. 9. signaling protein secreted by macrophages and neutrophils in response to infection or injury; immune modulation, inflammation response, promote blood flow.
  6. 11. produced by mast cells in inflammatory response and causes blood vessels to dilate and become more permeable to tissues.
  7. 13. fluid rich in white blood cells, dead pathogens, cell debris from damaged tissues.