Innate Immunity

3. vasoactive molecules; histamine and serotonine
5. mast cells lead to _________ which increases vascular permeability
6. predominant at later stages of inflammation
7. leukocyte chemotaxis --> leukocytes are drawn to areas of _______ which have increased chemockines
8. ex: dendritic cells, macrophages, mast cells; pro-inflammatory and antimicrobial mediators
10. Type _____ interferons: produced by virus-infected cells; non-specific response to viral infection; IFN-α & IFN-β -> inhibit viral replication & induce an antiviral state
11. damages the mucopeptides in the bacterial cell wall
14. leukocyte extravasation--> Migration
16. _____ proteins: damage the bacterial cell wall
17. leukocyte extravasation--> Adhesion
19. ________ pathway: complement proteins are activated on microbial surfaces
20. predominant during acute inflammation

1. ________ pathways: activated by antibodies that bind to microbes or other antigens
2. active process of capturing and ingesting foreign objects/microorganisms
4. sequestrates iron thus inhibiting bacterial growth
6. breaches the cell membrane of the microbe, allowing water to rush into the cell
9. present once the adaptive immune system is engaged in the response
12. leukocyte extravasation --> Rolling
13. ________ pathway: activated when a carbohydrate-binding plasma protein, MLB, binds to terminal mannose residues on the surface of glycoproteins
15. use of oxygen and glucose increases several fold "respiratory burst"
18. these cells recognize and respond to infected and stressed cells; secretion of IFN-γ -> stimulates and activates macrophages