International Pathology Day 2025

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Across
  1. 3. Term for the nuclear feature in papillary thyroid carcinoma resembling ground glass
  2. 4. Which test is used to detect latent tuberculosis infection using interferon gamma release?
  3. 6. What test is used to detect abnormal haemoglobin variants like HbS or HbC?
  4. 8. What is the term for the irreversible nuclear fragmentation seen in necrotic cells?
  5. 9. Term for the histological appearance of ‘salt and pepper’ chromatin in neuroendocrine tumours
  6. 14. What is the most likely cause of caseating granulomas in a lung biopsy in New Zealand?
  7. 16. Cellular change where nuclei appear dark, irregular, and hyperchromatic, but mitoses are absent
  8. 18. Which prion disease causes rapidly progressive dementia and spongiform changes in the brain?
  9. 19. Term for the phenomenon where tumour cells mimic endothelial cells to form vascular-like channels
  10. 22. Histological artefact caused by delayed fixation, often mistaken for necrosis
  11. 23. Process by which macrophages fuse into multinucleated cells in granulomatous inflammation
  12. 24. In “Star Trek,” what fictional disease causes rapid aging and cellular degeneration?
  13. 25. What is the name of the virus in “I Am Legend” that mutates into a lethal pathogen?
Down
  1. 1. Which scientist discovered the ABO blood group system?
  2. 2. Which fictional disease in “The Expanse” causes crystalline growths and cellular fusion?
  3. 5. Which fictional disease in “Doctor Who” causes people to turn into gas-mask-wearing zombies?
  4. 7. Term for the phenomenon where necrotic tissue calcifies in a non-metastatic setting
  5. 10. Term for the fibrotic capsule surrounding a chronic abscess
  6. 11. Which Star Trek medical officer was known for saying “I’m a doctor, not a…” in various episodes?
  7. 12. Who developed the Pap smear for cervical cancer screening (First name)?
  8. 13. Term for the paradoxical coexistence of cellular proliferation and apoptosis in neoplastic tissue
  9. 15. Which test offered by CHL quantifies the active form of vitamin D, useful in renal disease assessment?
  10. 17. Term for the phenomenon where tumour cells invade nerves
  11. 20. Histological pattern seen in invasive lobular carcinoma, often described as ‘single file’
  12. 21. Pathological term for the appearance of eosinophilic cytoplasmic inclusions in alcoholic hepatitis