Investigative Toxicology Crossword

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Across
  1. 4. Region of siRNA responsible for off-target activity
  2. 5. Rachel is certified to a depth of 60 feet in this underwater aquatic sport
  3. 7. Species used for ocular but not CNS or liver tox studies
  4. 10. RISC blocking modification commonly used in iTox studies
  5. 11. Co-author of this crossword
  6. 15. reporter assay used for on- and off-target activity assessment
  7. 19. biomarkers of liver injury
  8. 20. New group helping others with in-vitro experiments
  9. 21. Holiday that Alan dressed up as for HalloWEBB
  10. 22. iTox member with the longest tenure at Alnylam
  11. 25. Another co-author of this crossword
  12. 26. Elizabeth competes nationally in this sport
  13. 30. Humanized liver mouse model that recapitulates human ALT elevations with GalNAc-siRNAs
  14. 31. Anushka lived in this city in the UK until the age of 4
  15. 34. Organ that most of our drugs target
Down
  1. 1. Rate limiting step of siRNA uptake
  2. 2. GNA and 3' RNA are this type of chemical modification that increase siRNA specificity
  3. 3. siRNA building blocks that are assessed for safety by iTox
  4. 6. Blerta moved to the USA from this country at the age of 17
  5. 8. Strain of rats commonly used in iTox studies
  6. 9. Commonly used tool in the cell culture room
  7. 12. Proud mother of 3
  8. 13. In-vitro hepatocyte model commonly used for met ID studies
  9. 14. Saket's hobby/passion since his childhood and subject matter for a minor during undergrad
  10. 16. Space on the fourth floor where the youngest employees of the team work
  11. 17. CNS toxicity observed with noisy siRNAs
  12. 18. Presented "ASO vs. siRNA Distribution and Rodent Toxicity Comparison" in December 2021
  13. 19. Yongfeng's favorite sport
  14. 23. One of the co-chairs of SAGA Saket
  15. 24. Former fed
  16. 27. full-timer with shortest tenure in the group
  17. 28. Organ system currently targeted by C16
  18. 29. Maja played this musical instrument "semi-professionally" for years while growing up
  19. 32. Organ type that is our newest target
  20. 33. Presented "Facilitating Hepatocyte Uptake to Improve ED Max KD of GalNAc-siRNAs" in June 2022