IPID Crossword Puzzle

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Across
  1. 1. Cell adhesion molecule
  2. 6. family name for cytokines that help cells to resist viral infections; type 1 interferons include IFN-alpha and IFN-beta, as distinguished from IFN-gamma.
  3. 8. Human immunodeficiency virus
  4. 9. Systemic lupus erythematosus: autoimmune disease where autoantibodies (against DNA, RNA, and proteins associated with nucleic acids) form immune complexes
  5. 12. tumor necrosis factor-alpha: a cytokine produced by macrophages and T cells that is highly pro-inflammatory
  6. 16. large mononuclear phagocyte that takes residence in many different tissues and organs and contributes to innate immune responses and can act as an effector cell in adaptive immune responses
  7. 19. Immunoreceptor tyrosine-based activation motifs: amino acid sequence in cytoplasmic domains of membrane receptors involved in signal transduction
  8. 21. a cell wall component of gram negative bacteria which can be bound by TLR-4 on macrophages and dendritic cells
  9. 23. Subset of CD4+ T cells characterized by the cytokines they produce, including IFN-gamma involved in fully activating macrophages, and IL-2 involved in promoting CTL responses against intracellular pathogens
  10. 25. Surface immunoglobulin: an immunoglobulin that is expressed on B cell surface
Down
  1. 2. Autoimmune regulator: a transcription factor that causes several hundred tissue-specific genes to be transcribed by a subpopulation of epithelial cells in the thymus
  2. 3. Toll-like receptor: a family of Pattern Recognition Receptors present on many leukocytes and epithelial cells that recognize PAMPs on pathogens and help initiate immune responses
  3. 4. immunoglobulin secreted by plasma cells
  4. 5. general designation of many of the different cytokines, chemical messengers secreted by immune cells that help in their communication with other cells
  5. 7. Recombination signal sequences: short DNA sequences flanking Ig and TCR V, D and J gene segments that serve as the binding sites for the RAG complex, allowing Ig and TCR gene rearrangement (somatic recombination)
  6. 10. thymus-derived lymphocyte that are comprised of two different subsets, CD4 T cells and CD8 T cells
  7. 11. a molecule that is recognized in native (original) structure by antibodies or B cell receptor, or a peptide that is presented by MHC molecules to T cell receptor
  8. 13. Cell mediated immunity: adaptive immune responses in which there is a major role for effector T cells
  9. 14. Transcription factor expressed in Treg cells that is needed for Treg cell function
  10. 15. protein family to which antibodies and B-cell receptors belong
  11. 17. Family names of chemokines, chemicals that are a sub-class of cytokines with cell-attractant properties
  12. 18. Pathogen associated molecular patterns: repeating molecular patterns on microbes that are recognized by PRRs on immune cells
  13. 20. Highly active anti-retroviral therapy: multiple drug treatment for HIV infection
  14. 22. Cluster of differentiation: designation for specific cell-surface molecules on immune cells that help to differentiate one immune cell from another
  15. 24. Complementarity determining regions: the regions of the antigen binding loops of Ig molecules, antibodies and T cell receptors that come into contact with antigen