Key Cells of the Innate Immune System

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Across
  1. 6. Circulating granulocyte that releases histamine
  2. 8. Molecular pattern found on microbes but not host cells
  3. 10. Tissue mast cell mediator responsible for vasodilation
  4. 12. Circulating cell that differentiates into macrophages
  5. 14. Granulocyte involved in parasitic defence
  6. 15. First leukocyte recruited rapidly from blood during infection
  7. 16. Reactive molecule used by phagocytes to kill microbes
  8. 17. Innate lymphocyte that kills virus-infected cells
  9. 18. Cytokine that promotes acute inflammation and vascular leak
  10. 19. Cytokine responsible for induction of fever
Down
  1. 1. Vascular change causing redness and heat
  2. 2. Plasma protein cascade that opsonises microbes
  3. 3. Coating of microbes to enhance phagocytosis
  4. 4. Engulfment of particle by immune cells
  5. 5. Molecules released from damaged host cells
  6. 7. Physical barrier composed of keratinised cells
  7. 9. Resident tissue phagocyte that detects pathogens via PRRs
  8. 11. Lipid mediator derived from arachidonic acid
  9. 13. Small signalling protein released to coordinate immune responses