L21: Histamine

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Across
  1. 3. (abbreviation) this protein transports histidine into the TMN tract of the CNS
  2. 4. (abbreviation) enzyme required for the degradation of histamine
  3. 5. an inhibitor of MAO-B specific enzymes; in trials for treatment of Alzheimer’s disease
  4. 8. a partial agonist of H3 receptors
  5. 9. an inverse agonist of H2 receptors
  6. 10. an antagonist of H3 receptors (12 letters)
  7. 12. an inhibitor of MAO-A specific enzymes (11 letters)
  8. 14. (abbreviation) enzyme required for the synthesis of histamine
  9. 15. an antagonist of H2 receptors
  10. 17. an inhibitor of MAO-A specific enzymes (9 letters)
  11. 18. (abbreviation) this transporter packages histamine into vesicles in the TMN
  12. 19. an agonist of H3 and H4 receptors
  13. 20. a drug that can allow someone to stay up for 96 hours by increasing histamine release and thus, increasing alertness
Down
  1. 1. secreted by the GI system in response to food being ingested
  2. 2. an agonist of H2 receptors
  3. 6. an inhibitor of COMT-I enzymes
  4. 7. an inverse agonist of H3 receptors
  5. 8. an antagonist of H3 receptors (11 letters)
  6. 11. an inhibitor of MAO-A/MAO-B non-specific enzymes
  7. 13. an agonist of H1, H2, H3, and H4 receptors
  8. 14. HD acts on this substrate to produce histamine
  9. 16. when parietal cells secrete ___ acid when they detect histamine release