Laug OSU Winter 2025 - Immunology Exam 2 Study Tool Week 5

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Across
  1. 10. A naive CD4+ T cell that has not yet differentiated into Th1, Th2, or Th17.
  2. 11. A site within lymphoid follicles where B cells undergo proliferation, somatic hypermutation, and class switching.
  3. 12. Lymphoid tissue found in the small intestine that helps monitor gut microbiota.
  4. 14. Lymphoid tissue found in mucosal linings that helps protect against ingested or inhaled pathogens.
  5. 15. A secondary lymphoid organ that filters blood and helps mount immune responses against bloodborne pathogens.
  6. 16. A subset of CD4+ T cells that promotes cell-mediated immunity and fights intracellular pathogens.
  7. 19. A serine protease released by cytotoxic T cells and NK cells to induce apoptosis in infected or cancerous cells.
  8. 20. A subset of CD4+ T cells involved in defense against fungi and extracellular bacteria, and plays a role in autoimmunity.
  9. 23. The movement of immune cells between tissues, lymphoid organs, and circulation.
  10. 25. Clusters of lymphocytes within secondary lymphoid organs, often found in the germinal center.
  11. 26. A subset of CD4+ T cells that drives humoral immunity and helps combat parasitic infections.
  12. 27. Specialized epithelial cells in the gut that transport antigens from the intestine to Peyer’s patches.
Down
  1. 1. Specialized cells in lymphoid follicles that present antigen-antibody complexes to B cells.
  2. 2. A region of the spleen rich in T cells, surrounding central arteries.
  3. 3. Structures like lymph nodes, spleen, and MALT where immune responses are initiated.
  4. 4. A T cell-mediated immune response that occurs 24–72 hours after antigen exposure, such as in tuberculin tests.
  5. 5. Specialized blood vessels that allow naïve lymphocytes to enter lymph nodes from the bloodstream.
  6. 6. Activated immune cells that carry out immune responses, such as cytotoxic T cells and plasma cells.
  7. 7. A protein released by cytotoxic T cells and NK cells that creates pores in target cell membranes.
  8. 8. A subset of CD4+ T cells that helps B cells in the germinal center during antibody production.
  9. 9. Signaling molecules that direct the migration of immune cells to specific locations.
  10. 13. A co-stimulatory receptor on T cells that helps drive follicular helper T cell responses.
  11. 17. A subset of B cells found in the spleen that respond rapidly to bloodborne pathogens.
  12. 18. A programmed cell death mechanism that prevents inflammation and tissue damage.
  13. 21. A form of cell death that results in cell lysis and inflammation, often due to infection or injury.
  14. 22. Small, bean-shaped structures that filter lymph and serve as immune system hubs.
  15. 24. A ligand on antigen-presenting cells that binds ICOS to regulate T cell responses.