Lecture 17

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Across
  1. 3. diabetic ____________ is associated with degeneration of peripheral nerves
  2. 5. these cells secrete insulin
  3. 8. this hormone is released when blood glucose is too low
  4. 9. this kinase is activated by physiological stressors associated with obesity, stress and inflammation
  5. 10. phosphorylation of these amino acid residues on IRS-1 leads to insulin resistance
  6. 11. the insulin receptor phosphorylates targets on these amino acid residues
  7. 12. diabetic ___________ is the leading cause of blindness
Down
  1. 1. this enzyme phosphorylates glucose in the glycolysis cycle to ultimately produce ATP
  2. 2. insulin-producing cells are destroyed by this process in Type 1 diabetes
  3. 4. this biomarker reflects average blood sugar levels over the past 2-3 months
  4. 6. this calcium -dependent movement of insulin granules out of the cell
  5. 7. muscle cells express this transporter in their cell membrane to mediate glucose uptake