Lecture 19- Diabetes-Obesity
Across
- 4. muscle cells express this transporter in their cell membrane to mediate glucose uptake
- 7. leptin binds to these neurons to stimulate the release of this substance and create sense of satiety
- 8. this enzyme phosphorylates glucose in the glycolysis cycle to ultimately produce ATP
- 11. insulin-producing cells are destroyed by this process in Type 1 diabetes
- 12. the ob/ob transgenic mouse is deficient in _____________
- 14. this hormone stimulates differentiation of fat cells from multipotent stem cells
- 15. diabetic ____________ is associated with degeneration of peripheral nerves
- 17. this biomarker reflects average blood sugar levels over the past 2-3 months
- 18. phosphorylation of these amino acid residues on IRS-1 leads to insulin resistance
- 19. this calcium -dependent movement of insulin granules out of the cell
Down
- 1. the leptin receptor is located in the pituitary, reproductive system and this central brain gland
- 2. this hormone is released when blood glucose is too low
- 3. diabetic ___________ is the leading cause of blindness
- 5. having a large ________ size is associated with greater abdominal fat, and central adiposity
- 6. these cells secrete insulin
- 7. this syndrome is associated with insulin resistance, high triglycerides, central adiposity
- 9. this enzyme converts androgens to estrogens
- 10. this kinase is activated by physiological stressors associated with obesity, stress and inflammation
- 13. the insulin receptor phosphorylates targets on these amino acid residues
- 16. adipose tissue is comprised of these cells