Lecture 19- Diabetes-Obesity

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Across
  1. 4. muscle cells express this transporter in their cell membrane to mediate glucose uptake
  2. 7. leptin binds to these neurons to stimulate the release of this substance and create sense of satiety
  3. 8. this enzyme phosphorylates glucose in the glycolysis cycle to ultimately produce ATP
  4. 11. insulin-producing cells are destroyed by this process in Type 1 diabetes
  5. 12. the ob/ob transgenic mouse is deficient in _____________
  6. 14. this hormone stimulates differentiation of fat cells from multipotent stem cells
  7. 15. diabetic ____________ is associated with degeneration of peripheral nerves
  8. 17. this biomarker reflects average blood sugar levels over the past 2-3 months
  9. 18. phosphorylation of these amino acid residues on IRS-1 leads to insulin resistance
  10. 19. this calcium -dependent movement of insulin granules out of the cell
Down
  1. 1. the leptin receptor is located in the pituitary, reproductive system and this central brain gland
  2. 2. this hormone is released when blood glucose is too low
  3. 3. diabetic ___________ is the leading cause of blindness
  4. 5. having a large ________ size is associated with greater abdominal fat, and central adiposity
  5. 6. these cells secrete insulin
  6. 7. this syndrome is associated with insulin resistance, high triglycerides, central adiposity
  7. 9. this enzyme converts androgens to estrogens
  8. 10. this kinase is activated by physiological stressors associated with obesity, stress and inflammation
  9. 13. the insulin receptor phosphorylates targets on these amino acid residues
  10. 16. adipose tissue is comprised of these cells