Levetiracetam

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Across
  1. 1. About 66% of a dose is excreted ___ in urine
  2. 5. Minor metabolism is by enzymatic ___, not CYP450
  3. 6. Nootropic parent of the racetam family
  4. 10. Primary route of elimination, so dose by CrCl
  5. 15. Most common CNS adverse effect
  6. 16. Binds synaptic ___ protein 2A (SV2A)
  7. 17. Stop it this way to avoid withdrawal seizures
  8. 18. Behavioral effect, along with irritability, nicknamed "Keppra rage"
Down
  1. 2. Give a supplemental dose after this
  2. 3. Vitamin B6, sometimes tried for behavioral side effects
  3. 4. Analog with higher SV2A affinity (Briviact)
  4. 7. Seizure type in juvenile ___ epilepsy, an approved indication
  5. 8. Partial-onset seizures are now called ___ seizures
  6. 9. Usual immediate-release dosing: ___ daily
  7. 11. ___ epilepticus, where it's a second-line option
  8. 12. Weakness or fatigue adverse effect
  9. 13. Brand name of levetiracetam
  10. 14. Class warning for antiseizure drugs: ___ ideation