Lump of letters

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Across
  1. 2. which DNA repair enzyme family is pharmacologically inhibited to exploit synthetic lethality in BRCA1/2-deficient tumors?
  2. 6. long non-coding RNA that inhibits CyclinD-CDK complex
  3. 8. treatment given before main treatment (usually before surgery)
  4. 11. TNM system
  5. 12. give shape to cell
  6. 13. growth of new blood vessels to supply a tumor
  7. 14. mutation that is the first driver breaks key point of cell control/survival
Down
  1. 1. spreading of cancer
  2. 3. backup systems to make tumors resilient
  3. 4. family balancing apoptosis
  4. 5. targets dihydrofolate reductase (DHFR)
  5. 7. non-cancerous
  6. 9. abnormal mass of tissue
  7. 10. localized hypermutation clusters (often APOBEC enzymes)
  8. 12. platinum based cancer chemotherapy