Lymphocyte Development

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Across
  1. 3. what happens to a thymocyte following negative selection
  2. 4. antibody region that recognizes antigens
  3. 5. the target of an adaptive immune response
  4. 6. antibody region that is NOT modified during VDJ recombination
  5. 12. the development of specific cell types from progenitors
  6. 14. the set of unique lymphocytes in individuals that recognize distinct antigens
  7. 17. progenitor cell type that gives rise to T cells, B cells, NK cells
  8. 18. _______ exclusion prevents more than 1 antigen receptor being expressed on the same cell
  9. 19. lymphocyte subset that does not express antigen receptors
Down
  1. 1. site of T cell development
  2. 2. enzyme that promotes antigen receptor gene rearrangement
  3. 7. selection process that contributes to self tolerance
  4. 8. type of antigen recognized by T cells
  5. 9. molecule expressed on T cells that strengthens interactions with MHC/peptide complexes
  6. 10. B cell receptor
  7. 11. lymphocyte that has successfully developed through positive and negative selection
  8. 13. selection process that ensures a functional antigen receptor is produced
  9. 15. non-responsiveness to antigens
  10. 16. B cell receptor isotype