Major Diabetes Management Trials
Across
- 2. This trial (2019) is one of the first trials to demonstrate superiority of closed-loop insulin delivery systems in patients with T1DM
- 4. This trial (2009) showed that aggressive glycemic control in the ICU setting leads to increased mortality.
- 5. This 1970s trial used tolbutamide, insulin, and phenormin and is one of the earliest large-scale diabetes trials.
- 8. This trial (2021) showed that empagliflozin is superior to placebo in heart failure-related outcomes.
- 9. This trial (2008) was stopped early because an A1c goal of <6% led to increased mortality versus standard control.
- 10. This trial (1993) showed that intensive T1DM therapy delayed the onset of diabetic retinopathy and nephropathy
Down
- 1. This trial (2009) showed that the A1c target of <6.5% improved microvascular outcomes compared to conventional goals above 7%.
- 3. This trial (2016) was one of the first trials that showed that liraglutide improved CV outcomes versus placebo.
- 5. This trial (1998) showed a 25% risk reduction in microvascular endpoints with intensive diabetes treatment (A1c <7%).
- 6. This trial (2021) showed that when given together with metformin, liraglutide and insulin results in better glycemic control than glimpiride and sitagliptin.
- 7. This trial (2008) showed that in poorly controlled DM patients, intensive control had very little effect on major CV events or death.