medicinal chemistry
Across
- 2. Another term for adrenergic antagonist; blocks effects of sympathetic neurotransmitters.
- 5. A compound that binds to a receptor but does not activate it, blocking the effect of an agonist.
- 7. The fraction of an administered dose that reaches the systemic circulation in active form.
- 9. Chemical groups with similar physical or chemical properties that produce similar biological effects.
- 11. Inactive compounds that become active after metabolic conversion inside the body.
- 12. Peptide involved in vasoconstriction and blood pressure regulation.
- 14. The study of how the body absorbs, distributes, metabolizes, and excretes drugs.
- 17. Widening of blood vessels resulting from relaxation of smooth muscle in vessel walls, leading to increased blood flow and reduced blood pressure.
- 19. The process by which drugs move from the bloodstream to tissues and organs.
- 20. Include hydrogen bonds, ionic bonds, Van der Waals, and hydrophobic interactions that stabilize drug–target binding.
- 21. The biochemical modification of drugs, mainly in the liver, to facilitate excretion.
Down
- 1. Drugs that mimic the action of acetylcholine, stimulating parasympathetic responses.
- 3. The movement of a drug from its site of administration into the bloodstream.
- 4. A molecule that binds to a receptor and activates it to produce a biological response.
- 6. Drugs that increase urine formation and help reduce blood pressure and edema.
- 8. Refers to drugs or receptors related to adrenaline and noradrenaline actions.
- 10. Enzyme that plays a key role in the Renin-Angiotensin-Aldosterone pathway controlling blood pressure.
- 13. Condition treated with drugs that enhance cardiac output and reduce workload.
- 15. Drugs that block the action of acetylcholine in parasympathetic nerves.
- 16. Drugs that inhibit calcium ion entry into cardiac and smooth muscle, leading to relaxation.
- 18. Specific biological sites, such as enzymes or receptors, that drugs bind to in order to exert their effects.