Methotrexate Toxicity

2. MTX is ____% protein bound.
4. Monitor the patient's vital signs every ____hours for the first 24 hours.
5. MTX is an analog of what?
7. Most commonly used antidote for MTX toxicity.
8. MTX concentration leads to increased MTX ____.
11. In an overdose, cell death is seen more in organs with cells that divide rapidly, such as the GI tract and ____.
12. Patients must have a MTX level ____ than 0.10 µM to be discharged.
15. Administer____ if it was a recent overdose, the patient is not vomiting, and is able to maintain airway.

1. Enzyme MTX inhibits
3. What was MTX the first cure for?
6. What is needed for RNA and DNA synthesis that is inhibited by MTX
9. MTX is not selective for ____ cells, causing cytotoxic effects on healthy cells.
10. Formulation of MTX that is most common
11. MTX was first discovered in what City?
13. A term for inflammation of the mouth; risk of occurrence varies with dose of MTX.
14. Having No DNA or RNA synthesis leads to cytotoxic effects and ultimately cell____
16. Consider gastric lavage if a patient presents within____ hour(s) of overdose and has taken a life-threatening amount.