Midterm 2

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Across
  1. 6. released by Th cells to control killer T cells and create memory killer T cells
  2. 7. V, D, J, and C are involved in a gene rearrangement that makes up this chain
  3. 8. catalyzes CLIP release and competes against other peptides for the binding site of the class II MHC molecule
  4. 10. BCRs, TCRs, and antibodies attach to here on the antigen
  5. 11. most abundant antibody on mucous surfaces
  6. 12. 95% of TCRs are of this type
  7. 13. a process that BCRs undergo to increase affinity maturation for their cognate antigen (requires Th cell help)
  8. 15. involved in anaphylactic shock by degranulating mast cells
  9. 16. cell that provides class I and II MHC molecules along with co-stimulation to immune cells
  10. 18. class II MHC proteins present __ peptides
  11. 19. a mechanism changes the antibody production of a B cell when it is activated
  12. 21. is part of the ADCC mechanism
  13. 23. activated by TNF, killed cell chemicals, and/or PRRs (TLRs)
  14. 25. in charge of transporting peptides to class I MHC molecules
  15. 27. BCRs become __ to produce an activation signal because it clusters IG-alpha and IG-beta together
  16. 29. class I MHC proteins present __ peptides
Down
  1. 1. an exception to what class I MHC proteins typically present for antigens
  2. 2. restimulates T cells once they arrive during an infection
  3. 3. when an antigen binds on non-BCRs to cluster them along (and consequently BCRs as well); allows parasites to "distract" the immune system
  4. 4. the chain that prevents certain peptides from binding to the class II MHC molecule as it's being made
  5. 5. a complex in the cell membrane that moves the signal from the TCR outside to inside the cell's nucleus
  6. 6. TCRs on a mature T-cell are __
  7. 9. dendritic cells and Th cells first bind together with adhesion molecules to form an __
  8. 11. T-cell activation that involves danger signals in the environment
  9. 14. concentrates antigens for presentation
  10. 17. B or T cells that have not been activated are called __
  11. 20. the "1st antibody" that can fix complement proteins
  12. 22. CTLs express __ to clip to class I MHC molecules
  13. 24. Th cells express __ to clip to class II MHC molecules
  14. 26. the type of B-cell that cannot be produced in T-cell independent activation
  15. 27. the receptor on the T-cell that the B7 protein from the APC binds to
  16. 28. the type of arrangement for a full-length heavy chain protein