MSK drugs

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Across
  1. 3. an anti cholinesterase used to treat myasthenia gravis, starting with 'P'
  2. 4. peripheral acting non NMJ muscle relaxant; ryanodine receptor antagonist; inhibits Ca2+ release from internal stores of muscle cells
  3. 5. belongs to the amino steroid class; quick onset and recovery, allergic reactions
  4. 7. Xanthine Oxidase Inhibitor; 1st line preventative treatment of hyperuricaemia
  5. 9. preferred when Suxamethonium is contraindicated
  6. 11. central acting non NMJ muscle relaxant; adrenergic a2 receptor agonist
  7. 12. first line treatment for RA; block adenosine uptake, inhibition of T cells / B cells / IL-1β binding
  8. 13. Antimetabolite; inhibits dihydroorotate dehydrogenase; for more severe cases of RA; Poorly tolerated compared to methotrexate; hepatotoxicity
Down
  1. 1. central acting non NMJ muscle relaxant; first line; GABAb receptor agonist
  2. 2. atracurium, cisatracurium, mivacurium- these drugs belong to the class; short- intermediate action; histamine release association of flushing, hypotension
  3. 3. belongs to the amino steroid class and has a long duration & sympathomimetic activity
  4. 6. Antimetabolite; Prodrug; metabolites 5-aminosalicylic acid and sulfapyridine; used for RA treatment
  5. 7. pancuronium, rocuronium belong to this class; not associated with histamine release
  6. 8. an anti cholinesterase used to treat myasthenia gravis starting with 'n'
  7. 10. Depolarising blocker; nAChR agonist; fast acting- ideal for short procedures