Na channel blockers

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Across
  1. 7. : Has additional beta-blocker properties; avoid in asthma
  2. 9. : Contraindicated in structural heart disease post-MI
  3. 12. : Causes bone marrow suppression and hyponatremia
  4. 14. : Alternate name for phenytoin; narrow therapeutic index
  5. 15. : Used for ocular anesthesia; corneal toxicity if overused
  6. 16. : May cause kidney stones and weight loss
  7. 19. : May induce drug-induced lupus erythematosus
  8. 20. : Removed from market; pro-arrhythmic post-MI
  9. 22. : Can prolong PR interval; monitor ECG
  10. 23. : Similar to carbamazepine with lower hepatic interaction
  11. 24. : Also used for digoxin-induced arrhythmias and epilepsy
Down
  1. 1. : Risk of Stevens-Johnson syndrome with rapid titration
  2. 2. : Avoid in heart failure due to negative inotropic effect
  3. 3. : Ester-type local anesthetic; risk of PABA allergy
  4. 4. : Shortens QT; used in Lennox-Gastaut syndrome
  5. 5. : Used IV to treat post-MI ventricular arrhythmias
  6. 6. : Late sodium current blocker that prolongs QT
  7. 8. : Oral lidocaine-like drug for chronic ventricular arrhythmias
  8. 10. : Risk of hyponatremia; related to oxcarbazepine
  9. 11. : Withdrawn after CAST trial due to increased mortality
  10. 13. : Used in Brugada syndrome diagnosis; high arrhythmia risk
  11. 17. : Can cause QT prolongation leading to Torsades de Pointes
  12. 18. : Used for migraine prophylaxis and can impair cognition
  13. 21. : ENT anesthetic with vasoconstrictive and cardiotoxic effects