Neoplasia

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Across
  1. 4. This immunotherapy provides the patient with mature effector cells or antibodies that recognize and destroy tumors
  2. 6. Only having one copy of a working gene is not enough for normal function
  3. 8. _____ _______ carcinogens are effective in the form in which they enter the body
  4. 14. _____ Therapy is when tumor cells can be forced to differentiate into more mature, near-normal cells
  5. 17. __________ tumors spread beyond the original host via physical transplantation following direct physical contact between animals of the same species.
  6. 18. Inhibited by the loss of cadherins in tumor cells during metastasis
  7. 19. This immunity mounts the most effective antitumor defenses
  8. 22. _________normal cellular genes that regulate cell growth and differentiation
  9. 23. Embryonic antigens that are normally not expressed in adult tissues
  10. 25. This part of the immune system is the first line of defense of against cancer cells and is the least specific immune response to tumor cells
  11. 26. Occurs when two pieces of chromosome arms break off and reattach inappropriately
  12. 27. Contains tissued derived from all three embryonic germ layers
Down
  1. 1. Antigens that act like tumor-specific antigens when expressed at high levels
  2. 2. _____ spread is when cancer cells spread across serosal surfaces of body cavities
  3. 3. In _______ the site is determined by the ability of tumor cells to interact with adhesion molecules on the endothelial surface
  4. 5. Process where the immune system recognizes and eliminates tumor cells
  5. 7. This paraneoplastic effect of ____ tumors secretes excess hormones
  6. 9. ____ _____hypothesis is when both alleles of a tumor suppressor gene must undergo mutation, a genetic “hit” for cancer to develop
  7. 10. Assigned by a pathologist
  8. 11. A mass consisting of mature skin and adnexa
  9. 12. Assigned by a clinician
  10. 13. The process by which a local tumor spreads to other sites within the body
  11. 15. Process by which the immune system identifies and kills microbially infected cells or foreign cells
  12. 16. The process of which tumor cells enter blood vessels or lymphatics
  13. 20. Platelets contribute to the metastatic process by _____ tumor cells from immune destruction
  14. 21. This immunotherapy is when there is stimulation of the immune response of the animal against the tumor
  15. 22. This protein detects DNA damage and signals for the cell cycle and apoptosis
  16. 24. Refers to normal mature tissue located in an abnormal location