Neoplasia

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Across
  1. 2. Process of new growth in which normal cells undergo irreversible genetic change
  2. 9. abnormal numbers of chromosomes
  3. 11. Benign tumor of adipocytes
  4. 12. tissue growth
  5. 18. extreme variability in nuclear size
  6. 19. wide variation in cell siza
  7. 20. growth factor that stimulates fibroblast and increase production of collagen
  8. 21. tumors spread beyond the original host via physical transplantation following direct physical contact between animals of the same species
  9. 23. ovarian and pancreatic adenocarcinomas spread transcoelomically, resulting in multiple tumor masses throughout the abdomen
  10. 25. process by which the immune system identifies and kills microbially infected cells or foreign cells
Down
  1. 1. wide variation in cell shape
  2. 3. an irreversible alteration of genetic material, first step of neoplastic transformation
  3. 4. antigens antigens present on both tumor cells and normal cells
  4. 5. Development of new blood vessels
  5. 6. spread Tumor invade through veins to reach the vena cava, commonly sarcomas
  6. 7. antigens antigens restricted to tumor cells
  7. 8. cancerous tumors that invade locally and spread by metastasis
  8. 10. outgrowth of initiated cells in response to selective stimuli, second step of neoplastic transformation
  9. 13. nonneoplastic supporting structures like blood vessels, fibroblast, and inflammatory cells
  10. 14. antigens embryonic antigens normally not expressed in adult tissue
  11. 15. noncancerous tumors that do not invade locally nor spread
  12. 16. malignant transformation, third step of neoplastic transformation
  13. 17. development of lymphatic vasculature in tumors
  14. 22. tumor consisting of tumor cells termed parenchyma
  15. 24. notable weight loss and debility
  16. 26. poor cell differentiation