Neuro Genes Escape Room

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Across
  1. 3. The most common cause of overlapping frontotemporal dementia and amyotrophic lateral sclerosis, highly associated with abnormal TDP-43
  2. 4. This autosomal dominant trinucleotide repeat expansion disorder (CAG repeats) that is most commonly seen in patients of Asian descent and leads to chorea, myoclonus, and seizures is due to a mutation on chromosome 12
  3. 6. Dravet's syndrome, which is a severe epilepsy syndrome associated with frequent seizures and multiple seizure types, is most commonly associated with a mutation in this gene
  4. 8. CADASIL is an autosomal dominant condition that causes multiple strokes in individuals without traditional vascular risk factors and is caused by a missense mutation on this gene on chromosome 19
  5. 10. Multiple schwannomas and meningiomas are concerning for neurofibromatosis type 2, located on this gene
  6. 11. Most common neurodegeneration with brain iron accumulation disease, associated with “eye of the tiger” sign on MRI
Down
  1. 1. A duplication in this gene on chromosome 17 leads to the most common type of charcot-marie-tooth syndrome
  2. 2. This X-linked disorder resulting in hyperuricemia, neuropsychiatric symptoms, self-mutilation, dystonia, and chorea is due to a mutation in this gene
  3. 3. A patient presents with migraine associated with weakness on one side of her body. The patient’s mother had episodes of ataxia and nystagmus. Their symptoms best localize to this gene
  4. 5. A patient with a wing-beating tremor, Kayser-Fleischer rings, and an MRI of the brain demonstrating the double panda sign will have a mutation on this gene
  5. 7. This gene does not cause Alzheimer’s but triples the risk of getting it
  6. 9. An autosomal dominant trinucleotide repeat expansion disorder (CAG repeats) that most commonly causes chorea and psychiatric manifestations is due to a mutation in this gene located on chromosome 4