Neuropharmacology Review

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Across
  1. 6. reduced drug effect over time requiring higher doses
  2. 7. benzodiazepine reversal agent
  3. 8. peripheral dopa-decarboxylase inhibitor; protects levodopa before BBB
  4. 13. sedative that preserves respiratory drive; used for ICU sedation
  5. 15. opioid reversal agent
  6. 16. main excitatory neurotransmitter for learning and memory
  7. 17. dissociative anesthetic; causes amnesia and increases BP/HR
  8. 18. potent opioid analgesic for severe pain or anesthesia adjunct
  9. 20. enzyme inhibitor that increases acetylcholine at synapses
  10. 23. receptor stimulation relaxes bronchial smooth muscle causing bronchodilation
  11. 24. neurotransmitter deficient in Parkinson disease
  12. 25. crisis SLUDGE symptoms from excess acetylcholine
  13. 29. nervous system “fight or flight” division
  14. 34. primary parasympathetic neurotransmitter
  15. 35. stimulation causes vasoconstriction and increases blood pressure
  16. 36. osmotic diuretic to lower intracranial pressure
  17. 38. CNS depressant; enhances GABA; risk of respiratory depression
  18. 40. muscarinic agonist that stimulates urination
  19. 41. centrally acting antispastic for MS or spinal injury
  20. 42. short-acting IV benzodiazepine for rapid sedation or seizures
  21. 43. anticholinergic that reduces Parkinson tremor
  22. 44. GABA analog for neuropathic pain and partial seizures
Down
  1. 1. causes fetal malformations; avoid in pregnancy
  2. 2. side effects dry mouth, blurred vision, constipation, urinary retention
  3. 3. sedation scale used to assess agitation or sedation depth
  4. 4. drug class that stabilizes neurons to prevent seizures
  5. 5. broad-spectrum antiepileptic with few interactions
  6. 9. antiepileptic; risk of bone marrow suppression and rash
  7. 10. IV anesthetic; rapid onset, short duration; risk of hypotension
  8. 11. antiepileptic; notable risk of gingival hyperplasia
  9. 12. anticholinergic for overactive bladder; causes dry mouth
  10. 13. long-acting benzodiazepine for anxiety, seizures, muscle spasm
  11. 14. activation inhibits norepinephrine release (negative feedback)
  12. 16. main inhibitory neurotransmitter in CNS
  13. 19. receptor activated by epinephrine and norepinephrine
  14. 21. increased muscle tone from CNS injury; treated with baclofen
  15. 22. receptor activated by acetylcholine in smooth muscle and glands
  16. 26. tissue overgrowth from chronic phenytoin use
  17. 27. type of seizure risk when antiepileptics are stopped abruptly
  18. 28. selective barrier limiting CNS drug entry
  19. 29. depolarizing neuromuscular blocker for rapid intubation
  20. 30. nervous system “rest and digest” division
  21. 31. acetylcholinesterase inhibitor for myasthenia gravis
  22. 32. receptor stimulation increases heart rate and contractility
  23. 33. dopamine precursor that crosses the BBB for Parkinson disease
  24. 34. anticholinergic for bradycardia; dries secretions
  25. 37. primary sympathetic neurotransmitter
  26. 39. broad antiepileptic; hepatotoxic and teratogenic