Nucleotide metabolism

123456789101112131415161718192021222324252627282930313233343536373839
Across
  1. 2. reaction enzyme that converts NTPs to deoxyribonucleotides diphosphates
  2. 4. This enzyme is inhibited by purine and pyrimidine ribonucleotides
  3. 7. Donator of formyl group in purine biosynthesis
  4. 9. Purine base
  5. 14. Adenylosuccinate synthetase catalyzes the formation of IMP to _______
  6. 16. Adenylosuccinate lyase catalyzes the formation of AMP from adenylsuccinate with the ________
  7. 18. This enzyme catalyzes the conversion of xanthine to uric acid
  8. 20. First committed step; replaces the _______ of PRPP with the amide nitrogen
  9. 24. N1 of the purine structure originates from this molecule
  10. 26. Mutation in the HGPRT leads to this disease
  11. 27. This enzyme is responsible for most of the recycling of free bases
  12. 28. Orotidylate loses CO2 via Orotidylate Decarboxylase to form
  13. 30. Excess purines are degraded to ______
  14. 31. Starting material for purine biosynthesis
  15. 32. C2 of the purine structure originates from this molecule
  16. 34. Xanthine oxidase catalyzes the transfer of electron to oxygen to produce ________
  17. 35. Base of IMP
  18. 36. Precipitation of uric acid into joints and kidneys cause this disease
  19. 37. Pyrimidine base
  20. 38. product in regulated steps in pyrimidine biosynthesis
  21. 39. End product of purine de nove synthesis
Down
  1. 1. 2'C attached to H
  2. 3. This enzyme catalyzes the first committed step in pyrimidine biosynthesis
  3. 5. What is the rate-limiting enzyme of purine synthesis?
  4. 6. CPSII reaction takes place in the
  5. 8. ________ is oxidized to form Uric acid
  6. 10. Formation of this molecule is the committed step in the pyrimidine biosynthesis
  7. 11. N3 and N9 of the purine structure originates from this molecule
  8. 12. Nitrogen base, sugar, phosphate
  9. 13. Amidophosphoribosyl transferase is activated by this molecule
  10. 15. Analogue of hypoxanthine
  11. 17. Energy for AMP synthesis comes from ____
  12. 19. N-Carbamoylaspartate is CLOSED via Dihydroorotase to form __________
  13. 21. How many ATPs are consumed in pyrimidine biosynthesis?
  14. 22. The two rings of the purine base are synthesized bound to the _______ moiety
  15. 23. The rate of GMP synthesis increase with the concentration of _____
  16. 25. C4, C5, and N7 of the purine structure originates from this molecule
  17. 29. What enzyme makes PRPP from ribose-5-phosphate
  18. 33. Hypoxanthine is formed by deamination of __________