OCAT 6

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Across
  1. 7. Eraser that removes the marks HAT writes, so lysine grips DNA again; vorinostat blocks it. (18 letters)
  2. 8. Four letters for the intracellular histamine methylator. (4 letters)
  3. 12. Bricklayer that only adds to an existing 3' end and sweeps back over its work to fix errors; can't start without a primer. (10 letters)
  4. 14. Greek for fire: each added base releases PPi and luciferase flashes. (4 letters)
  5. 16. Ruska's 1931 trick: seeing with a beam that isn't light, revealing synaptic vesicles. (18 letters)
  6. 19. Absorbs one colour and emits another, so labelled proteins glow under the microscope. (11 letters)
  7. 22. Keeps the oxygen its cousin dropped, trades one letter of the alphabet, and does everything from carrying the message to building the factory. (3 letters)
Down
  1. 1. Antibodies that glow to show where a protein sits in the cell. (18 letters)
  2. 2. Smallest piece of quilt: Neher and Sakmann sealed a ___ of membrane to a pipette. (5 letters)
  3. 3. German for 'fattening': tissue cells stuffed with granules, a degranulation specialist. (4 letters)
  4. 4. Western by another name: antibodies on a membrane. (14 letters)
  5. 5. Earl of 1971 who unmasked cAMP while chasing adrenaline's effect on liver. (10 letters)
  6. 6. Swedish first name of Hammarskjold, and a lipid companion of IP3. (3 letters)
  7. 9. Escape artist moment: roughly ten nucleotides in, polymerase finally lets go of the promoter. (9 letters)
  8. 10. Four colours for four bases: ___-terminator. (3 letters)
  9. 11. Phosphate-pushers that move ATP's gamma phosphate onto Ser, Thr or Tyr. (7 letters)
  10. 12. Spelling without grammar: the order of amino acids from N to C, before any folding. (7 letters)
  11. 13. Heart of the matter: the minimal ~40 bp around the start site where pol II's platform is built. (4 letters)
  12. 15. Three letters from a jellyfish, fused to a protein to watch it live. (3 letters)
  13. 17. More seats than needed, so EC50 sits left of KD. (5 letters)
  14. 18. Out front, needs just one primer and never looks back; it runs the same way the fork does. (7 letters)
  15. 20. Surface chemist whose model of molecules sticking to a finite number of sites became drug-binding theory. (8 letters)
  16. 21. Gossip over the garden fence: the message reaches next door, but never the postal service (the blood). (9 letters)