OCAT practice

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Across
  1. 1. If SMAD is inhibited by this molecule, then it cannot get phosphorylated to make a complex and it therefore cannot get translocated to the nucleus to get EMT/proliferation/etc. started.
  2. 6. I'm a receptor on the immune cell that PAMP binds to / detects PAMPs on the pathogen to signal the immune cell that something foreign has pulled up
  3. 8. chaperone; imma take the CTFR molecule and allow it to get processed and get it inserted into the membrane. im the protein escort and I act on the CFTR protein
  4. 9. I'm so excited to fire up some neurons to activate the pain pathway SQUEEEE!
  5. 11. I'm an intracellular signalling protein that takes TGFbeta signals and carries them from the cell membrane to the nucleus
  6. 12. Ionotropic glutamate receptor that allows and needs all sorts of ions to flow across the membrane, membrane is depolarized. I let in calcium ions. also known as coincidence detectors. remove mg to allow ca and na while k flows out.
  7. 13. I help the enzymes that turn cholesterol into progesterone
  8. 15. a way to measure pain through activity in the nervous system
Down
  1. 2. potentiator; i need to bind to the channel so it can open up. i open up the CTFR protein/channel. im the channel opener and I act on the CFTR channel!
  2. 3. I inhibit JAK1 and JAK2 to stop crazy cytokine and interferon responses
  3. 4. along with theca I help to make up the corpus luteum
  4. 5. I'm the grandmother of steroids, and I'm made from cholesterol!
  5. 7. sneak me into bird feed, they won't know!
  6. 10. I'm the cause for your cloudy days.
  7. 14. I'm phosphorylated by these frat boi kinases, I dimer up with a buddy, we move into the nucleus together and I bind DNA and turn on target genes like cytokines and ISGs