Opioids

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Across
  1. 2. short acting opioid antagonist used for overdose reversal
  2. 4. Brand name of extended-release oxycodone
  3. 6. Brand name of buprenorphine/naloxone combination
  4. 8. prescription antidiarrheal combined with atropine
  5. 11. OTC peripheral μ-agonist used for diarrhea
  6. 14. Highly potent synthetic opioid; transdermal patch available
  7. 15. Brand name for fentanyl transdermal system
  8. 16. biased μ-agonist designed to reduce β-arrestin–mediated respiratory depression
  9. 17. Gold-standard opioid for severe pain; active metabolite of heroin
  10. 19. Partial μ-agonist used in opioid use disorder
  11. 20. Prodrug requiring CYP2D6 for conversion to morphine; ineffective in poor metabolizers
  12. 22. Weak μ-agonist + SNRI activity; seizure risk
  13. 24. Brand name of naloxone nasal spray
Down
  1. 1. High-potency synthetic opioid; CYP3A4 substrate; significant overdose risk with inhibitors
  2. 3. metabolite that can accumulate and causes seizures
  3. 5. OTC antitussive with abuse potential at high doses
  4. 7. Semisynthetic opioid commonly combined with acetaminophen
  5. 9. for intrathecal administration only
  6. 10. opioid with lowest histamine release
  7. 12. causes precipitated withdrawal in patients on chronic opioids
  8. 13. Long-acting opioid; QT prolongation risk
  9. 18. non-opioid allosteric inhibitor of peripheral sodium NaV1.8 channels
  10. 21. brand name of opioid that has deadly drug interaction with MAO inhibitors
  11. 23. Brand name for hydromorphone