P1 Enzymes and Proteins (Part 1)

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Across
  1. 6. The preferred way to treat methanol poisoning. Acts as a competitive inhibitor.
  2. 7. Also known as GSH. Converts N-acetyl-p-benzo-quinone imine to non-toxic compounds. Levels of GSH decreased by generation of acetaldehyde.
  3. 8. The principal regulation of the rate of the citric acid cycle is the availability of
  4. 10. This type of poisoning results in both oxidative steps generating toxic intermediates
  5. 12. Alcohol Dehydrogenase catalyzes the conversion of methanol to this
  6. 13. The second step of methanol metabolism creates this toxic product which inhibits Cytochrome c Oxidase
  7. 14. ____ Dehydrogenase catalyzes the oxidation and detoxification of acetaldehyde, turning it into acetate
  8. 16. ___ Glycol poisoning can also be treated using fomepizole
  9. 17. ____ Ethanol oxidizing system; members of the cytochrome p450 family are upregulated upon chronic alcohol consumption
  10. 19. When a person who drinks alcohol excessively takes acetaminophen, increased levels of CYP2E1 preferentially catalyze the conversion of acetaminophen to this
  11. 20. The enzymes of the TCA cycle are located in this part of the mitochondria
Down
  1. 1. The TCA cycle is described as ____ because it involves both anabolic and catabolic processes.
  2. 2. One of the 3 regulated enzymes of glycolysis. Inhibited by its product glucose-6-phosphate
  3. 3. A young woman is doing intense aerobic exercise. Aerobic glycolysis is being used for the source of energy for the muscle activity. The carbons derived from glucose will enter the citric acid cycle in the form of
  4. 4. The major regulation of PFK is _____ control by the ratio of ADP to ATP.
  5. 5. The most important regulatory enzyme of glycolysis. The rate-limiting step most of the time
  6. 9. The first step in ethanol metabolism (catalyzed by alcohol dehydrogenase)is the oxidation of ethanol to form this toxic intermediate that causes hangovers
  7. 11. The products of the reaction catalyzed by pyruvate dehydrogenase in the liver are Acetyl-CoA, CO2, and
  8. 15. The isozyme responsible for phosphorylating hexoses in the liver. Not inhibited by anything.
  9. 18. The first step of ethanol metabolism can also be carried out in peroxisomes by the enzyme