Parkinson

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Across
  1. 2. Toxin tied to farm PD cases (8)
  2. 6. Gene flaw raising PD risk (8)
  3. 12. PD's costly care burden (8)
  4. 13. Caregiver's PD strain (7)
  5. 18. Ear's sound sensor lost in aging (8)
  6. 19. Chemical scarce in PD brain (8)
  7. 21. Life aspect dimmed by PD (7)
  8. 22. Drug to boost PD movement (8)
  9. 23. Hearing fade with age (10)
  10. 26. Dopamine's brake on movement (10)
  11. 27. Relay for motor signals (8)
  12. 28. Excitatory spark in PD pathways (9)
  13. 30. Pathway to ease motion (6)
  14. 33. Prime time for PD onset (7)
Down
  1. 1. Genetic culprit in PD (5)
  2. 3. Eases PD's unwanted twitches (9)
  3. 4. Route to curb extra moves (8)
  4. 5. PD's ear synapse defect (11)
  5. 7. Basal ganglia core for movement (7)
  6. 8. Signal launcher in basal ganglia (8)
  7. 9. Mood dip from PD stress (10)
  8. 10. Motor signal starter in brain (8)
  9. 11. Tremor surgery site (8)
  10. 14. Late PD issue causing tumbles (7)
  11. 15. PD's ear issue chemical (8)
  12. 16. Sluggish motion of PD patient (11)
  13. 17. Shiver at rest in Parkinson's (6)
  14. 20. Dopamine's motion starter (10)
  15. 24. Brain's outer motion planner (6)
  16. 25. Head blow boosting PD odds (6)
  17. 29. Protein mass in PD neurons (9)
  18. 31. PD patient's social cut-off (9)
  19. 32. Dopamine hub lost in PD (7)